SMPDL3B a novel biomarker and therapeutic target in myalgic encephalomyelitis, 2025, Moreau, Fluge, Mella et al

[DMissa]

I just went through 7 different gene expression datasets that I have for different cell types from people with ME/CFS and nothing for these two genes stood out as clearly altered or consistent in direction of change from a quick scan. I was hoping to see something because they could fit well into the story I am trying to fit together. At least much of the theme is consistent. And probably most importantly this is yet again more evidence for messed up lipid homeostasis in immune cell populations. I cannot recall a null or even tepid result in this space.