The Reification of the Clinical Diagnosis of ME/CFS as an Immune and Oxidative Stress Disorder: 2021, Maes et al

John Mac · Jan 29, 2021

Full title:
The Reification of the Clinical Diagnosis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) as an Immune and Oxidative Stress Disorder: Construction of a Data-Driven Nomothethic Network and Exposure of ME/CFS Subgroups

Abstract
The approach towards myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) remains in a permanent state of crisis with fierce competition between the psychosocial school, which attributes ME/CFS to the perception of effort, and the medical approach (Maes and Twisk, BMC Med, 2010,8,35).

The aim of this paper is to review how to construct a nomothetic model of ME/CFS using Partial Least Squares (PLS) path analysis and ensembling causome (bacterial translocation as assessed with IgM/IgA responses to LPS), protectome (lowered coenzyme Q10), adverse outcome pathways (AOP) including increased lysozyme, CD38+ T cell activation, cell-mediated immune activation (CMI), and IgM responses to oxidative specific epitopes and NO-adducts (IgM OSENO).

Using PLS, we trained, tested and validated this knowledge- and data-driven causal ME/CFS model, which showed adequate convergence, construct and replicability validity.
This bottom-up explicit data model of ME/CFS objectivates the descriptive narratives of the ME/CFS phenome, using causome-protectome-AOP data, whereby the abstract concept ME/CFS is translated into pathways, thereby securing the reification of the ME/CFS phenome.

We found that 31.6% of the variance in the physiosomatic symptom dimension of ME/CFS was explained by the cumulative effects of CMI and CD38+ activation, IgM OSENO, IgA LPS, lysozyme (all positive) and coenzyme Q10 (inversely).
Cluster analysis performed on the PLS-generated latent vector scores of all feature sets exposed three distinct immune groups of ME/CFS, namely one with increased lysozyme, one with increased CMI + CD38 activation + depressive symptoms, and another with increased bacterial translocation + autoimmune responses to OSENO.
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https://www.preprints.org/manuscript/202101.0623/v1

Amw66 · Jan 29, 2021

John Mac said: ↑

Full title:
The Reification of the Clinical Diagnosis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) as an Immune and Oxidative Stress Disorder: Construction of a Data-Driven Nomothethic Network and Exposure of ME/CFS Subgroups

https://www.preprints.org/manuscript/202101.0623/v1

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How do these three distinct groups relate to Youngers etc ?

Jonathan Edwards · Jan 29, 2021

Amw66 said: ↑

How do these three distinct groups relate to Youngers etc ?
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I wouldn't worry, the abstract indicates that this is pseudoscientific rambling and nothing more.
Claiming that a few correlations can magically be turned into 'reification' using abstruse terms and methods gets us nowhere.

Kitty · Jan 29, 2021

Jonathan Edwards said: ↑

I wouldn't worry, the abstract indicates that this is pseudoscientific rambling and nothing more.
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It does read as if someone's been trying to teach their AI to draft articles in preparation for the beginning of April.

Milo · Jul 30, 2021

The paper seems to have published but i cannot see any full text options.
https://pubmed.ncbi.nlm.nih.gov/34315375/

boolybooly · Aug 2, 2021

Take that psychobabblers !!!

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The Reification of the Clinical Diagnosis of ME/CFS as an Immune and Oxidative Stress Disorder: 2021, Maes et al

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