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(Thesis) Autoimmune aspects in ME/CFS: A literature study on indications of autoimmunity in ME/CFS [Swedish), 2020, Strahle

Discussion in 'BioMedical ME/CFS Research' started by Dolphin, Jun 30, 2020.

  1. Dolphin

    Dolphin Senior Member (Voting Rights)

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    From: Dr. Marc-Alexander Fluks


     
  2. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

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    Note that some bacteria express their own HSP60, so that may explain the cross-reactivity, rather than autoimmunity itself. HSP60 is an intracellular protein, so isn't normally exposed to the immune system so antibodies directed against human HSP60 would need its own explanation.

    I haven't read the study in detail as it is not in English.

    Aside:
    "Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity."
    https://www.jci.org/articles/view/118320
    And of interest to me:
    "Prevalence of Anti-Heat Shock Protein Antibodies in Cerebrospinal Fluids of Patients With Guillain-Barré Syndrome"
    https://pubmed.ncbi.nlm.nih.gov/15465612/
     
    Last edited: Jun 30, 2020
    Michelle and wigglethemouse like this.
  3. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    I think this may refer to Jonas Blomberg's interest in HSP.

    HSP60 antibodies are everywhere and normal. The titres may be a bit higher in some autoimmune diseases but so are antibodies to all sorts of things. They do not indicate infection triggered disease as far as we know. Maybe the best thing about this thesis is that the author seems to have concluded that nothing very obvious is to be found.
     
    FMMM1, TrixieStix and Michelle like this.

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