(Thesis) Autoimmune aspects in ME/CFS: A literature study on indications of autoimmunity in ME/CFS [Swedish), 2020, Strahle

From: Dr. Marc-Alexander Fluks

 

Note that some bacteria express their own HSP60, so that may explain the cross-reactivity, rather than autoimmunity itself. HSP60 is an intracellular protein, so isn't normally exposed to the immune system so antibodies directed against human HSP60 would need its own explanation.

I haven't read the study in detail as it is not in English.

Aside:
"Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity."
https://www.jci.org/articles/view/118320
And of interest to me:
"Prevalence of Anti-Heat Shock Protein Antibodies in Cerebrospinal Fluids of Patients With Guillain-Barré Syndrome"
https://pubmed.ncbi.nlm.nih.gov/15465612/

 

I think this may refer to Jonas Blomberg's interest in HSP.

HSP60 antibodies are everywhere and normal. The titres may be a bit higher in some autoimmune diseases but so are antibodies to all sorts of things. They do not indicate infection triggered disease as far as we know. Maybe the best thing about this thesis is that the author seems to have concluded that nothing very obvious is to be found.