Preprint Transfer of IgG from Long COVID patients induces symptomology in mice, 2024, Vidarsson+

I have measured all of them and GFAP in my own samples (very severe ME), all negative, but again, I did not expect them to be elevated, as I think we deal with something more akin to past 'acute injury' as opposed to 'neurodegeneration'. I think 'time of sampling' is paramount.

PS: If LC mouse models are somewhat informative about ME/CFS we would not expect to see Nfl but GFAP to be elevated.

 

I haven't had a chance to read the preprint yet so apologies if my question is answered in it.
Did they by chance monitor the mice to see if their LC resolved over time?

 

They monitored the mice for 12 weeks (iirc) and stopped after that. The mice had LC symptoms over that whole period, but they did seem to improve over that period.

 

Thank you very much.

 

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