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Tweets from Bhupesh Prusty

Discussion in 'BioMedical ME/CFS News' started by Sarah94, Feb 1, 2020.

  1. Mij

    Mij Senior Member (Voting Rights)

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    Deficits/disturbances of innate immune system can produce a wide range of disorders, including neuropsychiatric disorders.
     
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  2. Marky

    Marky Senior Member (Voting Rights)

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    Too bad. Seems to me more researchers should spend time getting constructive criticism, instead of clinging to own hypothesises. This is not directed at Prusty by the way, just a general advice that would probably move the field forward
     
  3. Snowdrop

    Snowdrop Senior Member (Voting Rights)

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    While I've been on twitter in the past and it has it's uses - I think BP would be much better served presenting any hypotheses, requests, findings, thoughts etc here. Just my opinion though. ;)
     
  4. ringding

    ringding Senior Member (Voting Rights)

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    I agree, but I guess we're biased!
    Still possible he might change his mind in future I suppose.
     
  5. dreampop

    dreampop Senior Member (Voting Rights)

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    I just don't see the need for a nonspecific hypothesis, but in any case you would think his research has been public and specific enough that his position is established in those areas. That and the me community is small and knowleadgable, we know what few researchers have contributed and try to champion them. Personally the grand statements are off-putting.

    Moving on, he asks about Eosinophlic Catanonic Protein in ME/CFS and people responded with some very specific published work

    https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1398-9995.1996.tb04570.x

    https://www.tandfonline.com/doi/abs/10.1300/J092v09n01_03
     
  6. FMMM1

    FMMM1 Senior Member (Voting Rights)

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    @Jonathan Edwards responded to a question I'd asked - haven't found Jonathan's post yet. Basically (from memory) he was highlighting that there is specialisation in T-cells e.g. MAIT cells are associated with mucosa. Jonathan was suggesting that a specialised class of T-cells, which were responsible for interpreting responses from other immune cells (command & control if you like), would produce something like that looks like ME. I.e. the system seems to be responding to a threat but it's actually responding to dysfunction in the command & control system.
     
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  7. Badpack

    Badpack Established Member (Voting Rights)

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    Prusty removed the complement pathway and the mitochondria went back to normal in his experiment. Thats a pretty big deal in my book tbh. I hope that ppl like Ron or alain moreau can recreate this with their Cfs model very soon. Definitely a lead that should be followed fast now.
     
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  8. lunarainbows

    lunarainbows Senior Member (Voting Rights)

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    What’s the complement pathway?
     
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  9. Aslaug

    Aslaug Senior Member (Voting Rights)

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    The complement system are molecules that complement the immune system. They can bind to cells/microbes and act as targets for the immune system. Some of them can kill cells/microbes on their own.
     
  10. wastwater

    wastwater Senior Member (Voting Rights)

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    Last edited: Jul 5, 2020
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