USA: National Institutes of Health (NIH) intramural ME/CFS study

Can someone tell me what GWAS means, please.

 

Genome Wide Association Studies.

 

Thank you.

 

Folks - I think I recall that Nath made some discovery i.e. in the NIH ME/CFS study - anyone know about that and/or when the results are due out - suggestion of 2023 above?

 

I believe I heard within the past 2 months that they are still working on publication(s?). But don't recall hearing anything more recent than that.
Caution - attitude
Data analysis takes a long time ya know. And because it's about ME, it has to be done on ME time (meaning slower than other things and with lots of pacing - because we've been waiting so long what's another year or decade or....)

 

Last we heard it would soon be ready to be sent for review. Which we heard a few times before, and could take a loooong time if the journals make it especially difficult.

But that's what they tell us, and they rarely tell us the truth, so who knows?

 

Last fall (2021), Nath and the study’s lead clinical investigator, Brian Walitt, began meeting every weekend to synthesize the findings and to write up the results. Nath, who has an extensive track record of publishing research in top journals, and whose research is cited more than 45,000 times in the medical literature, said, “I’ve never written a paper of this huge magnitude in my life. I feel badly that it’s taken so long. But we have so much to synthesize, Brian and I. Today we were working on the discussion section,” which usually appears at the end of a research report and tries to put the results in a larger context.
My bolding

https://www.s4me.info/threads/usa-n...ramural-me-cfs-study.2980/page-13#post-417607

 

Do we know if genome analysis was part of the intramural study?

 

Think there were whole genome sequences - roughly $1K each - so not that much for a study like this (there weren't many participants) - but that's just something I think I recall.

 

Thanks
You posted that end of December 2022 - 2.5 months ago - so may take months (at least) to get from submission (January ish) to publication -- assuming the manuscript clears immediately - unlikely.

 

I suspect the main cause of delay is and has been Covid. The ME/CFS study was halted so they could work on Covid, and I bet they are still mainly working on Covid. They have to complete work on other studies in any spare time they have or can make, and its not a lot.

 

How many months is the usual gap from submission to publication in these kinds of journals?

 

No idea but I'd guess fast track is three months --- if the reviewers engage in discussion, ask for sections to be revised --- a year could go by.

 

So we could easily be waiting until next year? :/

 

it can vary from a couple of months to well over a year, e.g., if major revisions are required. One thing that has improved is that after acceptance the article can be posted online fairly rapidly.

I wrote an email to Walitt and Nath to urge them to please submit a preprint online but they didn’t respond. I believe that Brian Vastag also urged them to publish a preprint.

 

The post was from May 2022, 10 months ago.

 

More from the post that John Mac linked to

 

We shouldn't lose sight of who it is that is whispering into Nath's ear.

 

Some interesting stuff here* --- seems a relatively new area of research so possibly a need to ensure the findings are abnormal --- no point in announcing this is the pathology --- then say it isn't.
*https://twitter.com/user/status/1569931171718639616