Snow Leopard
Senior Member (Voting Rights)
Seriously though, it is a shame the study couldn't be completed properly. I feel fairly sure that problems with blood circulation are part of the ME/CFS pathology.
If the treatment can't be blinded, perhaps there could be some objective outcomes. Activity level might be one, although that would have to be measured for quite a long time to make sure it really was objective - which means treatment for a long time too. Measures of orthostatic intolerance perhaps would be more responsive.
I agree, this study could have been really interesting.
Measures of 2 day CPET and peripheral blood flow would have been interesting, though that wouldn't have helped the recruitment figures very much.