After watching this yesterday my question is, would the complex V problem explain why there is a limit to how much we can do?
I can exceed this limit, indicating that the ability to generate energy is there, but there will be a price to pay in the form of a crash that forces me back to lower activity levels if I keep trying to push and do more. Maybe not immediately but it is unavoidable if the limits keeps being exceeded. So one could say that exertion diminishes the capacity for future exertion (in a way that is not normal).
Complex V recycles ADP into ATP and I vaguely remember that the idea that this process is impaired has been proposed before.