It's a little more coherent than that, though it's important to add that it's just a hypothesis. I would argue that among PRT advocates the "Fight or Flight" explanation is primarily meant as a way to convey to patients how mind states affect body states in ways that are biochemically measurable. The Fight or Flight response reminds us that *belief* in danger can have dramatic somatic effects. With a sufficient adrenaline surge, you can run on a sprained ankle, and it might save your life. Or your threat assessment may be way off (we're all error prone), and you were never in danger in the first place, but you still ran your ass off on a bad ankle.
You're right that energy surges and the suppression of pain are the opposite of energy disorders and pain syndromes. But the Fight or Flight explanaton doesn't stop at the moment when you have safely fled the real or imagined sabre tooth tiger. The hypothesis is a systemic one, as broadly outlined in the passage you quoted. When threat assessment becomes dysregulated, it can start acting within the space of our own bodies. The medical term for a dysregulated nervous system is central sensitization, which may not be connected to our flight or flight response at all (though it's not entirely implausible that it would be connected.) And there's no proof at present that central sensitization, while predictable and observable in several clinical contexts, is actually the explanation for any given pain syndrome (or fatigue disorder). That part gets overstated by PRT advocates, for what I would hope are largely good-faith reasons.
But the point is, neither is the underlying hypothesis pseudoscience. Dysregulated neurochemical systems are known to give rise to a whole host of somatic symptoms without any underlying local pathology, which puts the hypothesis that some chronic conditions may be dysregulatory phenomena on equal scientific footing with any number of proposed-but-as-yet-unvalidated hypotheses for the same conditions.
Not trying to prosyletize here; I just think some of what gets painted as "woo" in pain science boils down to poor communication by therapy communities who are mostly focused on techniques for which the evidence of effectiveness is stronger that the explanation of the etiology. As a medical hypothesis, it's completely coherent, though of course like all hypotheses it may well completely fail under duress.
It's a little more coherent than that, though it's important to add that it's just a hypothesis.
At least it’s research.Gosh, I'd forgotten that thread. It's hair raisingly bad research. Worth reading the discussion.
translate.google.com
There is no such thing as «mind states». Everything is biological, or biochemical if you want. The concept of a «mind» is an illusion, and is impossible if you want to adhere to what we know about physics.I would argue that among PRT advocates the "Fight or Flight" explanation is primarily meant as a way to convey to patients how mind states affect body states in ways that are biochemically measurable.
Again, this assumes some kind of «mind» that is separate from the body. It’s the very dualism that the biopsychosocial proponents claim to oppose.When threat assessment becomes dysregulated, it can start acting within the space of our own bodies.
Can you provide any sources for the claim that CS is «predictable» or «observable» in «clinical contexts»?And there's no proof at present that central sensitization, while predictable and observable in several clinical contexts, is actually the explanation for any given pain syndrome (or fatigue disorder).
Why would we assume good faith on their behalf? They have a very long track record of exaggeration and lying about everything from their own data to threats and needing protection from the police.That part gets overstated by PRT advocates, for what I would hope are largely good-faith reasons.
Hi @crispscone! Thanks for joining the discussion. I can sympathise with some of the things you say and I don't think anybody has problems with hypotheses, as long as they are also treated as such, which all to often does not seem to be the case. Unfortunately, it seems to me that this "woo" often impacts the lives of people quite directly.It's a little more coherent than that, though it's important to add that it's just a hypothesis. I would argue that among PRT advocates the "Fight or Flight" explanation is primarily meant as a way to convey to patients how mind states affect body states in ways that are biochemically measurable. The Fight or Flight response reminds us that *belief* in danger can have dramatic somatic effects. With a sufficient adrenaline surge, you can run on a sprained ankle, and it might save your life. Or your threat assessment may be way off (we're all error prone), and you were never in danger in the first place, but you still ran your ass off on a bad ankle.
You're right that energy surges and the suppression of pain are the opposite of energy disorders and pain syndromes. But the Fight or Flight explanaton doesn't stop at the moment when you have safely fled the real or imagined sabre tooth tiger. The hypothesis is a systemic one, as broadly outlined in the passage you quoted. When threat assessment becomes dysregulated, it can start acting within the space of our own bodies. The medical term for a dysregulated nervous system is central sensitization, which may not be connected to our flight or flight response at all (though it's not entirely implausible that it would be connected.) And there's no proof at present that central sensitization, while predictable and observable in several clinical contexts, is actually the explanation for any given pain syndrome (or fatigue disorder). That part gets overstated by PRT advocates, for what I would hope are largely good-faith reasons.
But the point is, neither is the underlying hypothesis pseudoscience. Dysregulated neurochemical systems are known to give rise to a whole host of somatic symptoms without any underlying local pathology, which puts the hypothesis that some chronic conditions may be dysregulatory phenomena on equal scientific footing with any number of proposed-but-as-yet-unvalidated hypotheses for the same conditions.
Not trying to prosyletize here; I just think some of what gets painted as "woo" in pain science boils down to poor communication by therapy communities who are mostly focused on techniques for which the evidence of effectiveness is stronger that the explanation of the etiology. As a medical hypothesis, it's completely coherent, though of course like all hypotheses it may well completely fail under duress.
Is that really the case though? I have not come across such strong evidence, perhaps this exists in other fields outside of the ME/CFS realm, could you perhaps provide some evidence that would be useful to this discussion?I just think some of what gets painted as "woo" in pain science boils down to poor communication by therapy communities who are mostly focused on techniques for which the evidence of effectiveness is stronger that the explanation of the etiology.
It's a possible interpretation of this model. And it is a model, not a hypothesis. It's not very convincing, as it seeks to explain symptoms, rather than coming out of real observations. It's a retro-explanation, it mostly takes things that happen after, and reattributes them as their own cause. Grandfather paradox in a model does not make for good science.I would argue that among PRT advocates the "Fight or Flight" explanation is primarily meant as a way to convey to patients how mind states affect body states in ways that are biochemically measurable. The Fight or Flight response reminds us that *belief* in danger can have dramatic somatic effects.
I was told that Maeve wouldn't have died had she addressed her underlying stress.
BPSIt’s BSP they’ve said it elsewhere, AL must be feeling pretty silly now!
Which makes it NOT therapy then. And so shouldn't get to use that term? Just a task to get people in large amounts of pain to spend their time/mind energy on?Pain Reprocessing Therapy.
Here’s the biggest study on it to date.
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2784694
Key Points
Question Can a psychological treatment based on the reappraisal of primary chronic back pain as due to nondangerous central nervous system processes provide substantial and durable pain relief?
Findings In this randomized clinical trial, 33 of 50 participants (66%) randomized to 4 weeks of pain reprocessing therapy were pain-free or nearly pain-free at posttreatment, compared with 10 of 51 participants (20%) randomized to placebo and 5 of 50 participants (10%) randomized to...
- JohnTheJack
- alan gordon chronic pain pain psychosomatic medicine
- Replies: 137
- Forum: Other psychosomatic news and research
At the 5-year follow-up, the care-as-usual and PRT arms reported about the same pain levels.
I don't like drawing on that example at all as its repugnant they do it. But I do have to point out (as we are talking about bad faith) the common sense that if someone is starving to death then the easiest way to reduce at least one stress isn't to withold providing appropriate, timely, medical and support for feeding 'on principle' or because of 'beliefs'.These people really know a thing or two about stress. That sentence alone is stressful.
It is when it is not even close to being adequately substantiated and is being prematurely rolled out in clinical and medico-legal settings, in a reckless unsafe manner, which it has been for decades, and still is in many clinics.But the point is, neither is the underlying hypothesis pseudoscience.
Oh please. This is not a problem with bedside manner or marketing, or 'anti-psych' stigma in patients, etc. That is just convenient well-worn excuses to deflect responsibility. Your premise is simply false....boils down to poor communication by therapy communities who are mostly focused on techniques for which the evidence of effectiveness is stronger that the explanation of the etiology.
Last week, David Putrino, a neuroscientist and director of rehabilitation innovation at Mt Sinai Health System in New York, and a prominent investigator into possible biomedical mechanisms driving Long Covid, posted a call on social mediafor retraction of the article. His call appeared in response to an open letter to Wired posted by Scott Hugo, a housing rights attorney with Long Covid from Oakland, California.
I don’t expect much from Wired here. What has happened so far does not convince me that Wired, whatever its reputation, is “better than this,” as Putrino stated. I assume some of the country’s leading Long Covid advocates and advocacy groups have reached out to Wired privately to discuss the article, as would be common in such situations. Assuming that has happened, there have been no apparent impacts to date.
Wired has already failed to respond to what is clearly a serious violation of journalism ethics and practice. The story criticized an unnamed law professor for damaging scientific research, failed to follow basic journalism practices to seek her response, and then provided enough details about her for anyone to surface her name within seconds–in effect “outing” her to public scrutiny. In a tone-deaf series of responses on X, Levinovitz dismissed criticism of his actions as “wild” and “absurd.” (I wrote about this situation here.)
The violations of practice and ethics are glaringly clear to anyone who has taken Journalism 101–or anyone with common sense. Wired certainly understands that Levinovitz and the editorial team screwed up here. But they have ignored the two e-mails I sent raising questions about this matter.
If Wired can’t even be honest in acknowledging and making corrections, it would be foolish to expect honesty in how they deal with larger issues about the piece.
I am reposting below a blog about a “living systematic review” of interventions for Long Covid, which was published by The BMJ in late 2024. This systematic review figured prominently in the opening of the recent Wired piece about mind-body interventions for Long Covid. (I’ve posted about the Wired piece here, here and here.) The journalist—Alan Levinovitz, a professor of religion at James Madison University in Virginia—presented the systematic review’s conclusions uncritically. He did not discuss the review’s serious shortcomings, which raise questions about the reliability of its conclusions.
Here’s what Levinovitz wrote in Wired about the systematic review near the top of his story:
“The BMJ’s systematic review of ways to treat long Covid lists two as supported by moderate evidence, cognitive behavioral therapy and physical exercise. But if you attended the third annual Long Covid International Conference in Boston—as I did, late last year—you’d think the BMJ was encouraging medical malpractice. During two days of presentations, the world’s leading scientific authorities brought up exercise only to warn against it. Cognitive behavioral therapy received just one mention: ‘not recommended.'”
For Levinovitz, this negative attitude toward cognitive behavior therapy (CBT) and exercise is odd and hard to understand. That’s not surprising, given his apparent belief that 60-80% of Long Covid cases are “psychogenic,” per an X posting last year. However, what is actually odd and hard to understand is why major journals like The BMJ continue to publish work featuring errors that would be obvious to first-year epidemiology students at Berkeley.
Perhaps the Long Covid International Conference attendees didn’t focus on these interventions because they knew that many of their patients had already tried them and had not improved, or had even gotten worse. Or perhaps the attendees already knew not to take these studies at face value. In unblinded trials of non-pharmacological interventions, reports of modest improvements in subjective measures are to be expected–even in the absence of an actual therapeutic effect. The study design alone ensures the presence of an unknown amount of bias, so findings must be taken with a huge amount of skepticism.
My colleague and friend Brian Hughes, a professor of psychology at the University of Galway, in Galway, Ireland, was less enamored of the BMJsystematic review than Levinovitz. Back when it was published, he issued a sharp critique on his blog, The Science Bit. His post was titled “That BMJ review of Long Covid therapies does not show what it says it does.” Here’s a taste of his view:
“The authors are able to produce their findings only by looking at studies they themselves declare are biased. When these biased studies are excluded, the so-called evidence disappears…The BMJ review reveals that there is, in fact, NO UNBIASED EVIDENCE THAT CBT OR PHYSICAL REHABILITATION IMPROVE SYMPTOMS OF LONG COVID.”
Below is my blog about the systematic review—first posted on December 3, 2024. The review’s findings on exercise and CBT were largely based on two trials.
As I pointed out in that blog, the main trial in the systematic review that appeared to support exercise had been slapped with a major correction earlier in 2024. The correction made it completely clear that the trial’s findings only applied to patients who had been hospitalized for COVID-19, not to the larger Long Covid population. This key information does not appear in the most high-profile sections of the systematic review–even though the review was published after the correction.
In the trial that reported modest improvements in self-reported fatigue with CBT, the investigators had null results for their sole objective results–how far participants moved, as measured by a wearable device. Then, in a troubling lack of transparency, they failed to report these null results in the published paper. The systematic review, of course, also failed to mention the null results.
In any event, if experts at the Long Covid International Conference had read the BMJsystematic review, it wouldn’t be surprising if they ignored the conclusions–even though Levinovitz found the situation perplexing.
"Many people reading this may be familiar with a recent article on Long Covid recovery stories and ‘brain retraining’ published in Wired by the professor of religion Alan Levinovitz. In this piece, Levinovitz argues, somewhat bumptiously, that the sick patients who vehemently criticised ‘brain retraining’ as a valid treatment were exhibiting behaviour typical of religious belief: they believe, he argues, so fervently in a biological cause of illness that they neglect to consider non-pharmaceutical, mind-body treatments, such as ‘brain retraining’ that could actually help them, and crucify anyone for suggesting these practices.
Now is not time to exhume that argument, which, for many of us, has been laid to rest by virtue of our having tried brain re-training and gutted our health, but could I politely suggest that he might have considered the opposite: that the truly religious response might actually come from the Damascene converts who have undergone a miraculous recovery and are now trying to preach the truth of their experience to the rest of us. Ironically for a professor of religion, Levinovitz is surprisingly blind to the converts in his midst – and perhaps to his own impulses."
A very convenient coincidence of timing with the sustained increase in long-term pressure on health and welfare budgets.It also shifts responsibility back onto the patient, as well as making them an object to be related to as opposed to a participant; we become problems to be solved as opposed to patients to be cared for.
This.This is a group of patients laying in the mud, being kicked over and over, sometimes since childhood, until they’re so traumatised they don’t remember what safety feels like, including some who never got to experience it in their life, and we’re going to tell them to focus on thinking correct thoughts, while they are fighting to get their basic needs for survival met?
Online you’ll find a lot of young adults with ME sharing about living in an abusive situation at home that they can’t escape. Being given too little food, being mocked, and having zero emotional support, having missed out on their teenage years, while their peers experienced romantic relationships, gained independence and are creating families. All this suffering is in addition to the suffering from the illness itself.
If we wanted to calm the nervous systems of these ME patients, the first thing to focus on is adequate food, social belonging, kindness, necessary support for hygiene, access to medical care for unrelated issues that many with ME can’t access right now.