Preprint Worsening pre-existing health conditions in U.S. adults with Long COVID, 2026, Edwards et al.

Chandelier

Senior Member (Voting Rights)
Worsening pre-existing health conditions in U.S. adults with Long COVID

Edwards, Deja; Rollins, Alexandra; Ford, Nicole; Pratt, Caroline; Bloodworth, Robin; Pogreba-Brown, Kristen; Jones, Resa; Sharma, Vinita; Reina Ortiz, Miguel; Saydah, Sharon

Abstract​

Purpose Long COVID literature often describes new-onset symptoms or conditions following SARS-CoV-2 infection; however, Long COVID also encompasses the exacerbation of pre-existing conditions. We describe health conditions reportedly worsened by COVID-19 illness and associated concerns in U.S. adults.

Methods We collected longitudinal data from adults 18 years and older participating in the Track Post COVID-19 Conditions, an active Long COVID cohort surveillance project. Respondents completed surveys 3-, 6-, and 12- months after COVID-19 illness, beginning in July 2023. In each survey, respondents were asked whether they had any health conditions or concerns that were made worse by COVID-19.

Those with an affirmative response were asked to specify the worsening condition(s) via free text. Some respondents used this free text to describe challenges or experiences related to their worsening conditions. This report categorizes and quantifies reported conditions and concerns by body system categories and qualitatively describes associated challenges and experiences using direct quotes from respondents’ free text responses.

Results Among 2,227 adults, 263 (11.8%) respondents reported at least one worsening condition or concern following COVID-19 illness. Of these, nearly 32% reported a worsening respiratory condition or concern. Adults with worsening pre-existing conditions reported challenges accessing adequate care, completing daily activities, and managing their symptoms following COVID-19.

Discussion While Long COVID literature often focuses on the development of new-onset long-term symptoms, more than 1 in 10 adults reported worsening of a pre-existing condition following COVID-19. Reported challenges with accessing care and daily activities highlight potential need for accommodations or support for adults with Long COVID.

Web | DOI | medRxiv | Open Access
 



COVID may worsen existing health problems long-term, study suggests​

Laine Bergeson
September 28, 2026

More than one in 10 US adults reported that a preexisting health condition or concern got worse following a COVID-19 infection, according to a survey published last week on the preprint server medRxiv. Participants who reported worsening preexisting conditions also said they experienced challenges managing symptoms, completing daily activities, and accessing care.

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