Search results

This is incredibly exciting! Thank you to the whole team! P.s. i picked the wrong week to move house :eek:

Agreed. Hopefully if any theraputic experiments follow on from DecodeME they will include controls from the get go.

Mella said so in his Charite talk this year.

My definite (as opposed to possible prodromal) onset was after a dual strep and impetigo infection. Interestingly not the strain of strep that causes impetigo so two different infections. Point is bacterial infections definitely seem to be a trigger.

The question is have they created PEM in a dish or found the factor that causes ME/CFS exercise intolerance and muscle weakness/fatiguability? As opposed to delayed PEM.

Precicely i feel like they are talking about something that isnt neuroinflammation. These new drugs they are talking about are intriguing but I don't find it particularly compelling as a hypothesis.

I don't feel like the authors provide any evidence that neuroinflammation is the cause. And also is the definition that its 'immune activation within the brain' accurate? But the idea of targeting the sickness behavior itself rather than the cause of it is kind of intriguing. I guess time will...

Does the idea that its caused by neuroinflammation and will need new anti-inflammatory drugs to treat carry weight with anyone round here? It sort of seems like a shrug type response to me...

Do we know if the DecodeME team will be attending?

Yeah this work is facinating and if it replicates it could be really important.

What are the implications if this study replicates? If the factor in the serum causing these responses can be identified and removed, will cells and muscles return to normal? The paper calls these effects transient, so one would hope so... And would this finding gel or clash with the...

What was the sample size here, out of curiosity?

Yeah if I had a couple of weeks or a month I could maybe do something but 4 days is nowhere near enough time

This is a concern of mine too. I know JE and others are fairly confident there is going to be a sea change and I sincerely hope they are right, but I haven't seen concrete evidence of it yet. Perhaps we should brainstorm what we can do in the event government funding is not forthcoming. I think...

As someone who has had horrendous GI symptoms since covid at the end of 2020, I would be very interested to know if this bears out and also whether this drug is suitable for adults. Edit: Oh it's for MIS-C, I didn't clock that at first I thought general LC.

I have just watched Tronstad's talk - I am wondering if his theories are linked with Fluge and Mella's B cell stuff or if they are separate hypothesis? They are part of the same research group if I'm not mistaken.

Well that gives the opposite of confidence...

My memory is that his work didn't show anything beyond doubt, after he spend months encouraging everyone to board the biomarker hype train.

This is one of the most bizarre things about the psychobehavioural ideology: it is so immensely incredibly wasteful in myriad ways and yet nobody in power ever wakes up to it! As @rvallee has said elsewhere though, this situation could not exist without the deep prejudice and hatred doctors...

So how do we go about this then? Is it a case of wait for DecodeME and everything else, and then approach them as a community? Or is it more a case of someone who knows someone having a cosy chat with this hypothetical Addenbrokes professor in The Eagle?