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So was Leibniz a determinist then?

You're probably right. (although I am very concerned about my risk of CTE!)

I think for my personal case, sadly, if we take the view that environment is a factor, I probably wasn't likely to get it, or at least I wasn't likely to have more than a bout of post viral illness as my mum did in her twenties. In my late teens and twenties I had a lot of head injuries and...

Worsened hangovers at 19 were one of the first signs along with insomnia and DPDR that something wasn't right with me. When I got full ME/CFS seven years later the hangovers became even worse and I noticed feeling drunker with less alcohol although I was trying to cut down a lot on drinking at...

The current situation in terms of who has the power to shape care and public understanding is not 'balanced' in the slightest. It is weighted almost entirely towards what is the MECFS equivalent of climate change denial. The idea that we should be 'fair' by giving equal standing to the people...

'It’s true that the psychiatrists who hijacked this friendless disease decades ago weren’t using psychiatry to claim that ME isn’t “real”. They were, on the contrary, using ME to try and emphasise that psychiatry is real – “Look how properly actually sick your delusions have made you!” They’ve...

I wonder if something like the beds protests would work here. We have so many questions being asked about ME/LC now in parliament. If there was a similar way to turn up the heat on those with their hands on the purse strings by increasing visibility, especially if the demand was simply fund...

This is another study claiming elevated IL-6

Posts moved from thread: The LIFT trial (OMF) - Pyridostigmine (mestinon) and Low Dose Naltrexone (LDN) It looks like the Canadian one is six months past it's estimated completion date. I wonder why the silence.

How many people like me were dxed with depression and GAD pre ME/CFS? Anxiety is as bad a name for the DPDR and crippling panic attacks I experienced as chronic fatigue syndrome is for MECFS. As I've said before, I suspect my pre onset symtoms may have been a prodromal or very mild form of...

Me too. Or if either or the combination does turn out to do anything, so I can try it knowing that I'm not just risking nasty side effects and possible deterioation for nothing.

Was this in fibromyalgia? And can you say more or is this unpublished work you can't discuss?

All I know about this research group is what JE said about Paul Morgan here:

@Jonathan Edwards this is another study from Paul Morgan's group.

Abstract looks interesting, decent number of participants. Interested what people think.

Noting the reservations in the above posts (really hoping the responses aren't flukes, at least! ) If the responses and nk data are indeed real I would still have thought that occams razor would suggest that the separation is due to drug action. Do we have data on how patients with other...

Yes. Someone who would go to this length to prevent any criticism of PACE being published might not much like the idea of biomedical research funding...

The fact that Wessely is still acting like this behind the scenes in 2026 while proclaiming to be retired from ME research is disgraceful. This is why I get angry when people downplay his role in this and turn their nose up at attempts to expose him.

Any idea when we'll see your age of incidence paper? I'm really interested to read it.

That makes me think there's more of a chance the NK thing is about drug effect than a marker of subgroups or something mechanistic. If those numbers in non responders are really low and dara needs NK cells to work surely the simplest conclusion is that dara just isn't effective when NK cells are...