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I wanted to make a thread for environmental causes of ME because I have very high certainty (Edit: changing to "fairly high certainty") that the answer will ultimately lie in the modern environment - for ME, and likely for most chronic conditions. Traditional treatments like medications will be...

Link to S4ME thread on paper ---- Younger also mentioned that a group in the UK is planning a study testing FMT in ME/CFS. I couldn't find it in the UK trial registry (don't know how comprehensive that is compared to the US registry) but SolveME's site has a page about it:

https://www.sciencedirect.com/science/article/abs/pii/S1526590024004553 Abstract I can't access the full study, but based off Jarred Younger's summary on Youtube, this seems promising. 45 total participants. Active group received FMT + duloxetine. Control group received only duloxetine...

I might not be using the terminology correctly. Abnormality may be what I mean to say.

I'm not 100% sure what you mean by abnormal response, but presumably even that would theoretically produce a biomarker. Whether an altered set of genes, an altered brain region, I don't know. But if the body is doing something different, then something in the body is chemically different. And...

Over 10 years ago was the last time I had significant facial/vocal tics. This was during my worst depression/anxiety/fatigue, all significantly worsened by psych meds. But I've had no tics for years now. I rarely try any supplements or medications, since they're expensive, and of the dozens...

Dianna Cowern (Physics Girl) might be experiencing some benefit.

I love these! Thank you, and thanks to MIRAME arts. I'll share.

Wow, I forget sometimes how bad it can get, but I can see how a simple blood draw can turn into something terrible. Hopefully some possible ways to do so can be found, like non-traumatic/painful blood draw techniques, having a caregiver do all question answering, or at least find the most severe...

I don't know too much about the history of MS. What's the comparison to this? Elderly people is a good thought. On a somewhat related note, why in the world is every study not severe bedbound ME patients?? At least those that only require a blood draw. Presumably, any biomarker will be more...

You're right, I was writing too fast and wasn't thinking. So yes, when researchers are just looking at a new potential biomarker, like the nanoneedle test, it shouldn't be too hard to pop into the hospital and get some blood from patients, who probably already have a line set up in their arm...

I think that could provide some value if the questionnaire was thouroughly studied to not have many shortcomings. But I think hospitalized bedrest patients might be best. It's easy to find plenty of them - just look up "hospital" in the phone book. Maybe ask the nearest attending which patients...

Yes, what I've read is that curcumin by itself is almost completely destroyed by the digestive tract. Piperine from black pepper helps a bit. But there a various proprietary formulations that supercharge the bioavailability, many of which have been used in many studies assessing bioavailability...

I don't think whether they are healthy or not is important here if you also have a separate healthy control. The goal is to not only show that the marker shows different results from a healthy person, but that the level of exercise has nothing to do with the marker. As an example, given a study...

I think maybe step count could be a good proxy. Although that would add some complexity in the recruitment process. Maybe people diagnosed as severely depressed. Or maybe hospital patients on constant bedrest. But even if it's not perfectly defined between different researchers, I think even...

Well, I think it's important to include deconditioned and healthy. Because if it's just deconditioned vs. ME, then it's the opposite, and easy to say "it's because ME patients aren't actually sick."

I feel like as many trials as possible that compare ME/CFS to another group should include another deconditioned group, like sedentary depressed people. For example, I believe Ron Davis's nanoneedle test included healthy people and people with depression, though I don't know if they were...

I would assume it fundamentally doesn't change much. They whittle down both healthy and sick blood to smaller and smaller subsets of weight or type. Subsets which still have different effects on cells. Maybe they eventually see that the effect is still evident when both samples only have small...

I like this guy. Charismatic, humble, good at simplifying complicated subjects, and insists on listening to ME patients. Seems like a great advocate.

I've never heard of anything with stem cells + ME. Why is this a bad thing?