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That's if we know what environmental factors to look for. It might vary by exposure to industrial chemicals, which might not necessarily be obvious in location data. Maybe around half of most every region, every city, every neighborhood in the country by chance happens to use some specific...

I don't know specifics and haven't researched it myself, but as a starting point, I just asked claude.ai, and this seems like a significant influence of modern environment: "do any of these have good evidence for being at least partly caused by modern environmental factors, like chemicals or...

That's totally possible, thanks for the perspective. One of my main objections would be that it as far as I can tell, there is no evidence of significant prevalence of any ME/CFS-like disease in any wild animals. I asked a chatbot if they knew of anything similar: "are there any example of...

CDC: Notes from the Field: Long COVID Prevalence Among Adults — United States, 2022 Prevalence of reported experience of Long COVID among adults aged ≥18 years, by jurisdiction — Behavioral Risk Factor Surveillance System, United States, 2022 Abbreviations: DC = District of Columbia; GU =...

To add a bit, if my reasoning for it being unlikely that multiple different pathogens can be the root cause has some merit, then COVID would almost certainly not be a root cause, and is only exploiting a weakness opened up by previous insults to the body. Therefore, it may be highly valuable to...

You should be able to click the title in my last message. But here's the URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290765/

Systematic Review of the Epidemiological Burden of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Across Europe: Current Evidence and EUROMENE Research Recommendations for Epidemiology, 2020 It seems they weren't able to get much high quality data for Europe in 2020.

Yes, I don't think there's anything special about ME in this regard. Different genetics among the population could let the environment mess us up in different ways. That's unfortunate and would be the first place I'd look if I was pursuing an environmental factor. Though do we have any data on...

That's true, and I think the work should continue. But I think we should hedge our bets in case it is significantly environmental because trying to play detective with genes and blood feels like a much more roundabout, murky way of pinpointing an environmental cause, versus trying to see the...

I don't discount random internal events, and would be happy to say "genes + environment + random internal events" is the cause. Though, I don't think these random events by themselves would be the main or only cause, except in rare circumstances. I haven't extensively studied paleolithic humans...

I wanted to make a thread for environmental causes of ME because I have very high certainty (Edit: changing to "fairly high certainty") that the answer will ultimately lie in the modern environment - for ME, and likely for most chronic conditions. Traditional treatments like medications will be...

Link to S4ME thread on paper ---- Younger also mentioned that a group in the UK is planning a study testing FMT in ME/CFS. I couldn't find it in the UK trial registry (don't know how comprehensive that is compared to the US registry) but SolveME's site has a page about it:

https://www.sciencedirect.com/science/article/abs/pii/S1526590024004553 Abstract I can't access the full study, but based off Jarred Younger's summary on Youtube, this seems promising. 45 total participants. Active group received FMT + duloxetine. Control group received only duloxetine...

I might not be using the terminology correctly. Abnormality may be what I mean to say.

I'm not 100% sure what you mean by abnormal response, but presumably even that would theoretically produce a biomarker. Whether an altered set of genes, an altered brain region, I don't know. But if the body is doing something different, then something in the body is chemically different. And...

Over 10 years ago was the last time I had significant facial/vocal tics. This was during my worst depression/anxiety/fatigue, all significantly worsened by psych meds. But I've had no tics for years now. I rarely try any supplements or medications, since they're expensive, and of the dozens...

Dianna Cowern (Physics Girl) might be experiencing some benefit.

I love these! Thank you, and thanks to MIRAME arts. I'll share.

Wow, I forget sometimes how bad it can get, but I can see how a simple blood draw can turn into something terrible. Hopefully some possible ways to do so can be found, like non-traumatic/painful blood draw techniques, having a caregiver do all question answering, or at least find the most severe...

I don't know too much about the history of MS. What's the comparison to this? Elderly people is a good thought. On a somewhat related note, why in the world is every study not severe bedbound ME patients?? At least those that only require a blood draw. Presumably, any biomarker will be more...