Chandelier
Senior Member (Voting Rights)
Long-term angiogenic and thromboinflammatory signatures in post-COVID-19 syndrome
Paired plasma samples were collected during hospitalization and at long-term follow-up. Endothelial dysfunction markers included soluble P-selectin, vascular endothelial growth factor receptor 2, vascular endothelial growth factor D, and angiopoietin-1.
Hemostasis was assessed by prothrombin time.
Acute-phase proteins alpha-2-macroglobulin and haptoglobin were measured via immunoassay.
Persistent symptoms were documented at follow-up.
Vascular endothelial growth factor D and angiopoietin-1 remained elevated. Alpha-2-macroglobulin stayed high, and prothrombin time was prolonged in a subset of patients.
Elevated vascular endothelial growth factor D and angiopoietin-1 indicate ongoing angiogenic perturbations, while increased alpha-2-macroglobulin and prolonged prothrombin time reflect persistent coagulation disturbances.
These biomarkers may help identify long-term vascular alterations in post-COVID-19 syndrome.
Web | DOI | PDF | Angiogenesis | Open Access
Mora Zetina, Arlette Araceli; Ortega Sanchez, Erika Fabiola; Zuñiga Ascencio, Brenda Saraí; Castorena Maldonado, Armando Roberto; Ahumada Topete, Víctor Hugo; Torres Espíndola, Luz María; Aquino Gálvez, Arnoldo; Fernández Plata, Rosario; Higuera Iglesias, Anjarath Lorena; Martínez Briseño, David; Bernal Silva, Aranza; García Martín, Misael Osmar; Márquez García, José Eduardo; Moncada Morales, Angelica; Chávez Alderete, Jaime; Hernandez Zenteno, Rafael; Becerril Vargas, Eduardo; Cataneo Piña, Daniela Josefina; Aguilar Faisal, José Leopoldo; García Machorro, Jazmín; López Sánchez, Pedro; Hernandez Campos, María Elena; Castillejos López, Manuel
Abstract
Background
Post-COVID-19 syndrome is a major long-term sequela of severe SARS-CoV-2 infection, potentially involving persistent angiogenic and thromboinflammatory dysfunction, though long-term biomarker behavior remains unclear.Objective
To evaluate the evolution of angiogenic and thromboinflammatory biomarkers in post-COVID-19 syndrome patients.Methods
This ambispective cohort study was conducted at the National Institute of Respiratory Diseases in Mexico City. Thirty-two adults hospitalized for severe or critical COVID-19 in 2020 were followed for three and a half years.Paired plasma samples were collected during hospitalization and at long-term follow-up. Endothelial dysfunction markers included soluble P-selectin, vascular endothelial growth factor receptor 2, vascular endothelial growth factor D, and angiopoietin-1.
Hemostasis was assessed by prothrombin time.
Acute-phase proteins alpha-2-macroglobulin and haptoglobin were measured via immunoassay.
Persistent symptoms were documented at follow-up.
Results
At three and a half years, persistent symptoms were common: fatigue in sixty-five point 6%, dyspnea in sixty-two point 5%, and concentration difficulties in sixty-five point 6%.Vascular endothelial growth factor D and angiopoietin-1 remained elevated. Alpha-2-macroglobulin stayed high, and prothrombin time was prolonged in a subset of patients.
Conclusions
Severe COVID-19 survivors show sustained angiogenic dysregulation and thromboinflammatory imbalance.Elevated vascular endothelial growth factor D and angiopoietin-1 indicate ongoing angiogenic perturbations, while increased alpha-2-macroglobulin and prolonged prothrombin time reflect persistent coagulation disturbances.
These biomarkers may help identify long-term vascular alterations in post-COVID-19 syndrome.
Web | DOI | PDF | Angiogenesis | Open Access