decodemehit

The lead variant at this locus is 15:54866724:A:G (rs7165327) with a p-value of 7.62E-09. DecodeME labelled CCPG1 as a Tier 2 gene. The nearest protein coding genes are UNC13C (at 234,980 bp), and then RSL24D1 (at 314,073 bp). Though rs7165327 was a significant DecodeME hit, none of the nearest...

The 15th most significant locus in DecodeME is overlapping the gene DCC. The lead variant at this locus is 18:53232948:C:T (rs72923287) with a p-value of 2.48x10-7. GeneCards summary for DCC: Full gene name: DCC Netrin 1 Receptor "DCC" stands for "Deleted In Colorectal Carcinoma" The...

From a discussion on the Eccentric Medium Spiny Neurons thread: DecodeME identified HTT as of interest.

The locus near SHISA6 wasn't quite genome-wide significant, but it was close at p=8.26e-08. From GeneCards: Here is a plot of this locus (LocusZoom link): Edit: The lead variant at this locus is: 17:11,325,637:G:C / rs1546559

I didn’t see a thread about SOX6, apologies if I missed it SOX6 seems interesting as it is not only a peak in LocusZoom itself but also a Transcription Factor Binding Site mentioned in Genehancer data for promoters and enhancers for many (well most) other genes in the DecodeME candidate gene...

A quick look on AI. The NEGR1 (Neuronal Growth Regulator 1) gene, located on chromosome 1p31.1, encodes a GPI-anchored cell adhesion molecule critical for brain development, synaptic organization, and neuronal connectivity. Strongly associated with obesity, depression, and neurodevelopmental...

These are the main candidate genes suggested by the data from the DecodeME study based on different methods: Tier 1 and 2 genes as defined by the DecodeME paper, significant genes using MAGMA test, and the nearest genes to the top 25 most significant loci. I posted the same information on the...

One of the candidate genes in the DecodeME preprint. Curcumin increases PRDX6 expression.

DecodeME candidate ME gene From the Candidate Genes document CHROMOSOME 6p Chr6p contained seven Tier 1 genes. ******************** HFE (Tier 1) • Protein: Homeostatic iron regulator protein. UniProt. GeneCards. The allele that increases the risk of ME/CFS is associated with increasing HFE...

DecodeME candidate ME gene From the Candidate Genes document CHROMOSOME 20 Chr20 contained seven Tier 1 genes. *************** CSE1L (Tier 1) • Protein: Chromosome segregation 1-like (also known as exportin-2). UniProt. GeneCards. The allele that increases the risk of ME/CFS is associated...

DecodeME candidate ME gene From the Candidate Genes document CHROMOSOME 17 Chr17 contained one Tier 1 gene. **************** CA10 (Tier 1) • Protein: Carbonic anhydrase-related protein 10. UniProt. GeneCards. Note that this gene encodes a protein that lacks catalytic activity. The allele...

DecodeMe Candidate Gene CHROMOSOME 15 Chr15 contained no Tier 1 genes and one Tier 2 gene. ********************* CCPG1 (Tier 2) • Protein: Cell cycle progression 1. UniProt. GeneCards. • Molecular function: Involved in positive regulation of cell cycle and positive regulation of cell...

DecodeMe Candidate Gene CHROMOSOME 13 Chr13 contained no Tier 1 genes and one Tier 2 gene. ******************** OLFM4 (Tier 2) • Protein: Olfactomedin-4. UniProt. GeneCards. • Molecular function: OLFM4 facilitates cell adhesion, most probably through interaction with cell surface lectins...

CHROMOSOME 12 (GWAS-2) Chr12 contained three Tier 1 genes. Image of the 2025 DecodeME results by @ME/CFS Science Blog: ******************** SUDS3 (Tier 1) • Protein: SIN3A corepressor complex component, also known as SDS3. UniProt. GeneCards. The allele that increases the risk of ME/CFS is...

DecodeME candidate ME/CFS gene ******************** FBXL4 (Tier 2) • Protein: F-box/LRR-repeat protein 4. UniProt. GeneCards. • Molecular function: Component of the mitochondria-localised SCF-FBXL4 ubiquitin E3 ligase complex. This complex restricts mitophagy by controlling the degradation...

DecodeME identified variants that passed the genome-wide significance threshold at this locus: DecodeME candidate ME/CFS gene CHROMOSOME 6p Chr6p contained seven Tier 1 genes. *************************** BTN2A2 (Tier 1) • Protein: Butyrophilin subfamily 2 member A2. UniProt. GeneCards...

From DecodeME Candidate Genes: RABGAP1L (Tier 1) • Protein: RAB GTPase-activating protein 1-like, also known as TBC1D18. UniProt. GeneCards. The allele that increases the risk of ME/CFS is associated with decreasing RABGAP1L gene expression. • Molecular function: GTP-hydrolysis activating...