depression

Nuclear factor kappa-B cell NF-κB, interferon regulatory Factor, and glucocorticoid receptor pathway activation in major depressive Disorder: The role of cytomegalovirus infection Savitz; McKinney; Meier; Zheng; Ford; Yolken; Teague; Cole Altered activity of major immunoregulatory pathways has...

FDA approves first app-based treatment for major depressive disorder https://time.com/7086622/depression-treatment-app-rejoyn/ The app, called Rejoyn, is cleared as a supplement to currently approved therapies and works by using specifically designed tasks on a smartphone app to rewire neural...

Viral infections are increasingly recognized as triggers for depressive disorders, particularly following the SARS-CoV-2 pandemic and the rise of long COVID. Viruses such as Herpes Simplex Virus (HSV), Epstein-Barr Virus (EBV), Cytomegalovirus (CMV), and Human Immunodeficiency Virus (HIV) are...

Full title: Use of passively collected actigraphy data to detect individual depressive symptoms in a clinical subpopulation and a general population. The presentation of major depressive disorder (MDD) can vary widely due to its heterogeneity, including inter- and intraindividual symptom...

Posts split from a regional thread Isn't this true? Edit: I must have misremembered seeing more about mental illness being a risk factor. I'm not seeing much now though. Closest I found so far is: A logistic regression analysis of risk factors in ME/CFS pathogenesis, 2019, Lacerda et al

Objective: Comorbidities between internalizing disorders (IDs) and functional disorders (FDs) are well-documented, indicating shared pathways. However, their symptom-level relationships have been largely unexplored. This exploratory study employs a network approach to investigate symptoms of...

Abstract The heterogeneity and complexity of symptom presentation, comorbidities and genetic factors pose challenges to the identification of biological mechanisms underlying complex diseases. Current approaches used to identify biological subtypes of major depressive disorder (MDD) mainly...

Physiological presentation and risk factors of long COVID in the UK using smartphones and wearable devices: a longitudinal, citizen science, case–control study Callum Stewart; Yatharth Ranjan; Pauline Conde; Shaoxiong Sun; Yuezhou Zhang; Zulqarnain Rashid; Heet Sankesara; Nicholas Cummins...

Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK 1088 Authors BACKGROUND COVID-19 is known to be associated with increased risks of cognitive and psychiatric outcomes after the acute phase of...

A Descriptive Diagnosis or a Causal Explanation? Accuracy of Depictions of Depression on Authoritative Health Organization Websites https://karger.com/psp/article-abstract/doi/10.1159/000538458/909052/A-Descriptive-Diagnosis-or-a-Causal-Explanation?redirectedFrom=fulltext Abstract...

Preferential and sustained platelet activation in COVID-19 survivors with mental disorders Maugeri, Norma; De Lorenzo, Rebecca; Mazza, Mario Gennaro; Palladini, Mariagrazia; Ciceri, Fabio; Rovere-Querini, Patrizia; Manfredi, Angelo A.; Benedetti, Francesco Pre-existing mental disorders are...

Beyond the serotonin deficit hypothesis: communicating a neuroplasticity framework of major depressive disorder Chloe E. Page, C. Neill Epperson, Andrew M. Novick, Korrina A. Duffy, Scott M. Thompson Abstract The serotonin deficit hypothesis explanation for major depressive disorder (MDD) has...

Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety https://www.nature.com/articles/s41591-024-03057-9 There is an urgent need to derive quantitative measures based on coherent neurobiological dysfunctions or ‘biotypes’ to enable stratification of...

Abstract Background: Paediatric chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) has a prevalence of 0.4–2.4% and is defined as ‘generalised disabling fatigue persisting after routine tests and investigations have failed to identify an obvious underlying cause’. One-third of young...

The outcomes of mental health care for depression over time: A meta-regression analysis of response rates in usual care https://www.sciencedirect.com/science/article/pii/S0165032724007377 Highlights Response rates in usual mental health care have not improved over time. Only about one in...

Effect of exercise for depression: systematic review and network meta-analysis of randomised controlled trials BMJ 2024; 384 doi: https://doi.org/10.1136/bmj-2023-075847 (Published 14 February 2024) Cite this as: BMJ 2024;384:e075847 Michael Noetel, senior lecturer1, Taren Sanders, senior...

Cortical GABA Levels Are Reduced in Post-Acute COVID-19 Syndrome Marinkovic, Ksenija; White, David R.; Alderson Myers, Austin; Parker, Katie S.; Arienzo, Donatello; Mason, Graeme F. After recovering from the acute COVID-19 illness, a substantial proportion of people continue experiencing...

Efficacy and Safety of Antidepressants in Patients With Comorbid Depression and Medical Diseases An Umbrella Systematic Review and Meta-Analysis JAMA Psychiatry: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2809163 Key Points Question What is the evidence for use of...

Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of mental health symptoms in patients with post-acute sequelae of SARS-CoV-2 infection (PASC) INTRODUCTION Post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection...

Exercise as medicine for depressive symptoms? A systematic review and meta-analysis with meta-regression https://bjsm.bmj.com/content/57/16/1049 Objective To estimate the efficacy of exercise on depressive symptoms compared with non-active control groups and to determine the moderating...