depression

Preliminary clinical and cost effectiveness of augmented depression therapy versus cognitive behavioural therapy for the treatment of anhedonic depression (ADepT): a single-centre, open-label, parallel-group, pilot, randomised, controlled trial...

World Psychiatry Journal The lived experience of depression: a bottom-up review co-written by experts by experience and academics Paolo Fusar-Poli, Andrés Estradé, Giovanni Stanghellini, Cecilia Maria Esposito, René Rosfort, Milena Mancini, Peter Norman, Julieann Cullen, Miracle Adesina, Gema...

The largest and most impactful trial of depression of all time has now been reanalysed using individual participant data obtained from the NIMH. The STAR*D trial was originally published in the American Journal of Psychiatry in 2006 and has amassed over 5,000 citations. It cost the US taxpayers...

Associations between symptoms and functional capacity in patients after COVID-19 infection and community controls Quan Huynh; Noah Wexler; Joel Smith; Leah Wright; Felicia Ho; Richard Allwood; Yusuke Sata; Stefano Manca; Erin Howden; Thomas H. Marwick Background: Post-acute sequelae of COVID-19...

Microglia Transcriptional Profiling in Major Depressive Disorder Shows Inhibition of Cortical Gray Matter Microglia https://www.biologicalpsychiatryjournal.com/article/S0006-3223(23)01239-8/fulltext Biological psychiatry Microglia have been implicated in the pathophysiology of major depressive...

Many questionnaires used to measure depression ask about general symptoms such as fatigue, sleep, appetite, concentration etc. People with a chronic illness such as ME/CFS already have those symptoms and are thus more likely to score high on these depression questionnaires, even if they are not...

Higher immune-related gene expression in major depression is independent of CRP levels: results from the BIODEP study https://www.nature.com/articles/s41398-023-02438-x Abstract (paragraphs mine) Compelling evidence demonstrates that some individuals suffering from major depressive disorder...

Abstract Depression is often framed as a disease or dysfunctional syndrome, yet this framing has unintended negative consequences including increased stigma. Here, we consider an alternative messaging framework – that depression serves an adaptive function. We describe the historical...

https://news.sky.com/story/electric-headset-for-treating-depression-trialled-by-nhs-12884293

The impact of fibromyalgia syndrome on obstructive sleep apnea syndrome in terms of pain threshold, daytime symptoms, anxiety, depression, disease severity, and sleep quality: a polysomnographic study Abstract Background Current studies have focused on the association of fibromyalgia syndrome...

How the Lancet lost our trust Stuart Ritchie The Spectator (UK) 26/06/2021 A few of us have tried to get Ritchie interested in the PACE trial, but he has previously refused. But since it now seems to support his argument, he does cautiously mention it...

Full title: Presence of depression and anxiety with distinct patterns of pharmacological treatments before the diagnosis of chronic fatigue syndrome: a population-based study in Taiwan Abstract Objective An increased prevalence of psychiatric comorbidities (including depression and anxiety...

Sex differences in the blood-brain barrier: Implications for mental health Dion-Albert L, Bandeira Binder L, Daigle B, Hong-Minh A, Lebel M, Menard C Prevalence of mental disorders, including major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia (SZ) are increasing at...

After an appeal by Janssen (the pharmaceutical company that manufactures esketamine) in July, NICE reviewed the evidence they submitted again in a technology appraisal guidance (TAG) and recommended against its use for treatment-resistant depression. The TAG committee’s discussion is an...

Study finds first direct evidence of a link between low serotonin and depression From the Guardian, science correspondent: Link to the study: BRAIN SEROTONIN RELEASE IS REDUCED IN PATIENTS WITH DEPRESSION: A [11C]Cimbi-36 PET STUDY WITH A D-AMPHETAMINE CHALLENGE.

I thought I'd post this (rather long) article from The Guardian, about a new book by Dr Siddhartha Mukherjee. It discusses depression and the search for a new paradigm to describe and understand it. It interested me because in a sense, it would be helpful to do something similar with brain fog...

Key Points Question Is psychological distress before SARS-CoV-2 infection associated with risk of COVID-19–related symptoms lasting 4 weeks or longer, known as post–COVID-19 conditions? Findings This cohort study found that among participants who did not report SARS-CoV-2 infection at...

Abstract The causes of depression are diverse and are still not fully understood. Recently, an increasing role is attributed to nutritional and inflammatory factors. The aim of this study was to evaluate selected metabolites of the tryptophan kynurenine pathway in depressive patients with small...

Abstract Introduction Brain fog has been described up to 1 year after SARS-CoV-2 infection, notwithstanding the underlying mechanisms are still poorly investigated. In this study, we aimed to evaluate the prevalence of cognitive complaints at 1-year follow-up and to identify the factors related...

Abstract Primary Sjögren’s syndrome (pSS) is an autoimmune disease with frequent neurological involvement. Memory complaints are common, but their precise patterns remain unclear. We wanted to characterize patterns of neurocognitive profiles in pSS patients with cognitive complaints. Only pSS...