depression

Higher immune-related gene expression in major depression is independent of CRP levels: results from the BIODEP study https://www.nature.com/articles/s41398-023-02438-x Abstract (paragraphs mine) Compelling evidence demonstrates that some individuals suffering from major depressive disorder...

Abstract Depression is often framed as a disease or dysfunctional syndrome, yet this framing has unintended negative consequences including increased stigma. Here, we consider an alternative messaging framework – that depression serves an adaptive function. We describe the historical...

https://news.sky.com/story/electric-headset-for-treating-depression-trialled-by-nhs-12884293

The impact of fibromyalgia syndrome on obstructive sleep apnea syndrome in terms of pain threshold, daytime symptoms, anxiety, depression, disease severity, and sleep quality: a polysomnographic study Abstract Background Current studies have focused on the association of fibromyalgia syndrome...

How the Lancet lost our trust Stuart Ritchie The Spectator (UK) 26/06/2021 A few of us have tried to get Ritchie interested in the PACE trial, but he has previously refused. But since it now seems to support his argument, he does cautiously mention it...

Full title: Presence of depression and anxiety with distinct patterns of pharmacological treatments before the diagnosis of chronic fatigue syndrome: a population-based study in Taiwan Abstract Objective An increased prevalence of psychiatric comorbidities (including depression and anxiety...

Sex differences in the blood-brain barrier: Implications for mental health Dion-Albert L, Bandeira Binder L, Daigle B, Hong-Minh A, Lebel M, Menard C Prevalence of mental disorders, including major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia (SZ) are increasing at...

After an appeal by Janssen (the pharmaceutical company that manufactures esketamine) in July, NICE reviewed the evidence they submitted again in a technology appraisal guidance (TAG) and recommended against its use for treatment-resistant depression. The TAG committee’s discussion is an...

Study finds first direct evidence of a link between low serotonin and depression From the Guardian, science correspondent: Link to the study: BRAIN SEROTONIN RELEASE IS REDUCED IN PATIENTS WITH DEPRESSION: A [11C]Cimbi-36 PET STUDY WITH A D-AMPHETAMINE CHALLENGE.

I thought I'd post this (rather long) article from The Guardian, about a new book by Dr Siddhartha Mukherjee. It discusses depression and the search for a new paradigm to describe and understand it. It interested me because in a sense, it would be helpful to do something similar with brain fog...

Key Points Question Is psychological distress before SARS-CoV-2 infection associated with risk of COVID-19–related symptoms lasting 4 weeks or longer, known as post–COVID-19 conditions? Findings This cohort study found that among participants who did not report SARS-CoV-2 infection at...

Abstract The causes of depression are diverse and are still not fully understood. Recently, an increasing role is attributed to nutritional and inflammatory factors. The aim of this study was to evaluate selected metabolites of the tryptophan kynurenine pathway in depressive patients with small...

Abstract Introduction Brain fog has been described up to 1 year after SARS-CoV-2 infection, notwithstanding the underlying mechanisms are still poorly investigated. In this study, we aimed to evaluate the prevalence of cognitive complaints at 1-year follow-up and to identify the factors related...

Abstract Primary Sjögren’s syndrome (pSS) is an autoimmune disease with frequent neurological involvement. Memory complaints are common, but their precise patterns remain unclear. We wanted to characterize patterns of neurocognitive profiles in pSS patients with cognitive complaints. Only pSS...

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions Major depression is a debilitating psychiatric illness that is typically associated with low mood and anhedonia. Depression has a heritable component that...

Joanna Moncrieff, Ruth E. Cooper, Tom Stockmann, Simone Amendola, Michael P. Hengartner & Mark A. Horowitz The serotonin hypothesis of depression is still influential. We aimed to synthesise and evaluate evidence on whether depression is associated with lowered serotonin concentration or...

Slide presentation: "Antidepressant withdrawal syndrome and its management" Dr Mark Horowitz BA, BSc, MBBS, MSc, PhD (IoPPN, KCL) Clinical Research Fellow on RADAR trial (UCL, NELFT) Psychiatry Trainee (Camden & Islington) m.horowitz@ucl.ac.uk...

Abstract Introduction This study examines the relationships among recent adverse childhood experiences (ACEs), somatic symptoms, and anxiety/depression symptoms during adolescence and whether anxiety/depression symptoms mediate the relationship between ACEs and somatic symptoms. Methods...

I wonder whether ME/CFS would be a better primary diagnosis for some of these people? https://www.sciencedirect.com/science/article/abs/pii/S0889159121000398 Brain, Behavior, and Immunity Volume 94, May 2021, Pages 259-265 Infectious mononucleosis as a risk factor for depression: A nationwide...

Highlights Longitudinal multiomics associate PASC with autoantibodies, viremia and comorbidities Reactivation of latent viruses during initial infection may contribute to PASC Subclinical autoantibodies negatively correlate with anti-SARS-CoV-2 antibodies Gastrointestinal PASC uniquely present...