pain

Autoantibodies mediate pain and sensory dysfunction in post-COVID syndrome Pain and fatigue are common but poorly understood features of post-COVID Syndrome (PCS). To probe the mechanistic basis of these symptoms, we investigated sensory functions in patients with widespread pain attributed to...

Tulane University: "Tulane scientists uncover new pain-signaling switch" 'Researchers found that nerve cells communicate outside the cell with the enzyme vertebrate lonesome kinase (VLK), which can alter proteins in the space between neurons, affecting how those cells send signals. “This is...

Abstract This study aims to evaluate the impact of pain catastrophizing (PC) on disease activity in patients with rheumatoid arthritis (RA) and to explore, in the same participants, if this association is related or not with anxiety and depression, which have been related to catastrophization in...

I am still reading this… this is a very good summary by some leading researchers about the difficulties they have encountered in trying to develop non-opioid painkillers using the sodium channel Nav1.8. It’s been a difficult and perplexing process and there’s an immense amount of pressure to...

Can I ask if anyone has been given morphine to help with their dire pain and malaise. I’m taking codeine and pregablin plus duloxetine and nortriptyline. But I’m in dire agony now nearly all of the time. I’ve had a small bit of a friends morphine which helped me immensely but as yet cannot get...

Hormonal Fluctuations and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in Women: The Role of Menstrual Cycle and Menopause Mehak Khan, Sidra Anees, Muhammad Muthar Anees, Komal Khalid Chaudhry, Syeda Marium Rashid Zaidi, Vishan Das, Rimal Rashid [Line breaks added] Abstract Myalgic...

SLC45A4 is a pain gene encoding a neuronal polyamine transporter Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy1. They are implicated in multiple neurological disorders, including stroke, epilepsy and neurodegeneration, and can...

DecodeME candidate ME gene From the Candidate Genes document CHROMOSOME 17 Chr17 contained one Tier 1 gene. **************** CA10 (Tier 1) • Protein: Carbonic anhydrase-related protein 10. UniProt. GeneCards. Note that this gene encodes a protein that lacks catalytic activity. The allele...

Pain among US adults before, during, and after the COVID-19 pandemic: a study using the 2019 to 2023 National Health Interview Survey Zajacova, Anna; Grol-Prokopczyk, Hanna; Nahin, Richard L The unprecedented disruption of the COVID-19 pandemic raises crucial questions about its impact on...

Evidence for a role of skull bone marrow in human chronic pain as revealed by TSPO PET imaging The skull bone marrow is emerging as a critical hub for neuroimmune signaling in various disorders, with the potential to reshape how we understand brain-immune interactions. However, its role in...

Genome-wide association study identifies novel genetic variants associated with widespread pain in the UK Biobank, 2025, Pan Abstract Objectives: Widespread pain is a hallmark characteristic of fibromyalgia, commonly affecting older individuals. This study aimed to identify novel genetic...

Genome-wide association study of multisite chronic pain in UK Biobank, 2019, Johnston Abstract Chronic pain is highly prevalent worldwide and represents a significant socioeconomic and public health burden. Several aspects of chronic pain, for example back pain and a severity-related phenotype...

This is disapointing… …"This implies that experience of trauma and distress might elicit a specific immune-biological response in genetically or otherwise (eg, past infection, toxicity, trauma) vulnerable individuals, which includes the production of harmful noninflammatory autoantibodies." …...

SARS-CoV-2 N protein interacts with Nav1.7 to promote pathological pain Liu, Jin-Kun; Zhou, Zi-Su; Wang, Shu-Hang; Zuo, Shi-Yu; Lu, Xiao-Fan; He, Ying; Tang, Hao; Xie, Yan; Xie, Man-Xiu; Zhang, Xiao-Long Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome...

https://www.science.org/doi/10.1126/sciadv.abc5219 A role for proprioceptors in sngception Cheng-Han Lee https://orcid.org/0000-0003-3642-4115, Jiann-Her Lin https://orcid.org/0000-0002-7255-741X, Shing-Hong Lin https://orcid.org/0000-0002-8012-6935, Chu-Ting Chang...

Postacute COVID-19 syndrome and fibromyalgia syndrome are associated with anti-satellite glial cell IgG serum autoantibodies but only fibromyalgia syndrome serum-IgG is pronociceptive Berwick, Richard J.; Sahbaie, Peyman; Kenny, Grace; Guo, Tian-Zhi; Neiland, Harvey; Andersson, David A.; Clark...

323 - Toxic Exposures and Chronic Overlapping Pain Conditions in a Veteran Cohort: Gender-Specific Insights from the Million Veteran Program Armand Gerstenberger, Niloofar Afari, Marianna Gasperi [Line breaks added] Chronic overlapping pain conditions (COPCs) include migraine, tension...

368 - Relation of Immune Profile to Exercise-Induced Pain and Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-acute Sequelae of SARS-CoV-2 Infection Giovanni Berardi, Adam Janowski, Samuel McNally, Gregorius Bernhard, Alpana Garg, Kathleen Sluka Abstract Individuals with...

Highlights • Transplanting gut microbiota from women with fibromyalgia into mice induces pain • It also induces immune activation, metabolomic changes, and reduced skin innervation • Gut microbiota promotes pain through several mechanisms Summary Fibromyalgia is a prevalent syndrome...

Scientists pinpoint cause of migraines - paves way for new treatment