pain

Molecular architecture of human dermal sleeping nociceptors Human dermal sleeping nociceptors display ongoing activity in neuropathic pain, affecting 10% of the population. Despite advances in rodents, a molecular marker for these mechano-insensitive C-fibers (CMis) in human skin remains...

Excessive epithelial mechanosensation drives nociceptive innervation and chronic bladder pain via the PIEZO1-SLC7A11-glutamate axis Epithelial mechanosensation maintains tissue homeostasis by sensing mechanical stimuli. Dysregulated mechanotransduction has been implicated in chronic pain, yet...

Patterns of Muscle Health in Single- and Multi-Site Chronic Pain: A UK Biobank Normative Modeling Study BACKGROUND Chronic pain is associated with impaired muscle health, but whether these changes reflect site-specific factors, broader systemic factors, or both remains unclear. The purpose of...

Pain Neuroscience Education als Intervention zur Verbesserung der Lebensqualität bei Patienten mit chronischen Kreuzschmerzen Irle, Lisa; Alfuth, Martin Abstract Background Educational strategies that improve understanding of pain can influence the behaviour of patients with chronic low back...

Modulating neuroplasticity for chronic pain relief: noninvasive neuromodulation as a promising approach Abstract Abstract Chronic neuropathic pain is a debilitating neuroplastic disorder that notably impacts the quality of life of millions of people worldwide. This complex condition...

Education about pain and experience with cognitive-based interventions do not reduce healthcare professionals’ chronic pain Weisman, Asaf; Yona, Tomer; Masharawi, Youssef Background Cognitive-based interventions like pain neuroscience education (PNE), cognitive behavioral therapy (CBT)...

Adieu to an aphorism: why nociception is necessary for pain Weisman, Asaf; Quintner, John; Cohen, Milton Abstract An aphorism is a short saying intended to express a general truth. In this article, the popular aphorism, 'nociception is neither necessary nor sufficient for pain', is critically...

Psychophysiologic symptom relief therapy for chronic back pain: a pilot randomized controlled trial Introduction: Chronic back pain is the leading cause of disability in the United States. Based on the hypothesis that nonspecific back pain may be rooted in a psychophysiologic etiology, we...

Abstract Allodynia (perceiving touch as painful) is an enduring symptom of neuropathic pain. While acute pain is initiated by afferent signaling from the periphery to spinal cord, pain chronification recruits ongoing activity in supraspinal sites. One such site that has been proposed to be...

Perioperative outcomes in myalgic encephalomyelitis/chronic fatigue syndrome undergoing general anesthesia: a retrospective matched-pair study BACKGROUND Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic multisystem disease characterized by profound fatigue...

Until a few days ago, I did not know this award existed. I found this description of the co-winners of the prize. work to be interesting and a worthwhile read. This is one area where mouse models have contributed towards advancing the understanding of the human physiology. The complexity of...

Key Points Question Is transcutaneous electrical nerve stimulation (TENS) effective for treating pain when combined with physical therapy (PT) in individuals with fibromyalgia? Findings This cluster randomized clinical trial of 459 participants with fibromyalgia from 28 PT clinics from 6...

I am thankful I do not live in Spain. //////////////////////////////////////// Beliefs, attitudes, knowledge, and behaviours of physical therapists towards pediatric complex regional pain syndrome, 2026, Moutafakir et al Beliefs, attitudes, knowledge, and behaviours of physical therapists...

Multicenter randomized controlled trial of cognitive-behavioral, exercise-based, and combined interventions for juvenile fibromyalgia Abstract Abstract Juvenile fibromyalgia (JFM) is a complex and disabling chronic pain condition for which treatment options are limited. The objective of this...

Peak alpha frequency is associated with pain severity in Long COVID patients with new-onset chronic pain New-onset chronic pain is a common and debilitating symptom of Long COVID (LC) that remains not fully understood in terms of pathophysiology and therapeutic targets. A growing body of...

A cellular basis for heightened gut sensitivity in females Visceral pain disorders, such as irritable bowel syndrome, exhibit a marked female prevalence. Enhanced signaling between enterochromaffin (EC) cells in the gut epithelium and mucosal sensory nerve fibers likely contributes to this sex...

Associations Between Genetic Polymorphisms and Psychological Variables in Women With Fibromyalgia: A Cross‐Sectional Study, 2025, Riquelme‐Aguado et al. ABSTRACT Introduction Fibromyalgia (FM) is a multifactorial syndrome involving chronic pain and psychological distress. Psychological traits...

Microglial Activation in Nociplastic Pain: From Preclinical Models to PET Neuroimaging and Implications for Targeted Therapeutic Strategies Nociplastic pain has recently been introduced as a third entity for identifying patients suffering from chronic pain that arises from altered nociception...

Autoantibodies mediate pain and sensory dysfunction in post-COVID syndrome Pain and fatigue are common but poorly understood features of post-COVID Syndrome (PCS). To probe the mechanistic basis of these symptoms, we investigated sensory functions in patients with widespread pain attributed to...

Tulane University: "Tulane scientists uncover new pain-signaling switch" 'Researchers found that nerve cells communicate outside the cell with the enzyme vertebrate lonesome kinase (VLK), which can alter proteins in the space between neurons, affecting how those cells send signals. “This is...