sars-cov-2

Recent SARS-CoV-2 infections and increased antibody responses to viral antigens are associated with greater autoantibody reactivity BACKGROUND SARS-CoV-2-induced latent autoimmunity may play a role in long-COVID symptoms. This study explored associations between serum immunoglobulin G (IgG)...

Identification of the SARS-CoV-2 genome packaging signal in the nsp12-coding region Abstract Selective genome packaging is a critical step for RNA viruses, which must distinguish genomic RNA from other abundant transcripts. For SARS-CoV-2, the cis-acting packaging signal is thought to be...

Background and Objectives: Post-COVID-19 syndrome (PCS), characterized by persistent fatigue, can develop after a SARS-CoV-2 infection. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, post-infectious condition marked by severe fatigue and post-exertional malaise. This...

Persistent Immune Dysregulation during Post-Acute Sequelae of COVID-19 is Manifested in Antibodies Targeting Envelope and Nucleocapsid Proteins https://www.biorxiv.org/content/10.1101/2025.08.18.670908v1 Abstract Post-Acute Sequelae of SARS-CoV-2 infection (PASC) syndrome or “Long COVID”...

Evolutionary rewiring of host metabolism and interferon signalling by SARS-CoV-2 variants SARS-CoV-2 variants differ in transmissibility and immune evasion, but their effects on host-cell metabolism and signalling remain less defined. Using integrated transcriptomic, phosphoproteomic, and...

SARS-CoV-2 spike triggers TLR7-dependent endolysosome dysfunction and senescence in human astrocytes SARS-CoV-2 infection is associated with long-lasting neuropsychiatric and cognitive symptoms, collectively referred to as neuro-PASC. Emerging studies indicates that accelerate brain aging and...

A highly divergent sample from a nearly extinct SARS-CoV-2 lineage in a patient with long-term COVID-19 BACKGROUND Although COVID-19 is primarily an acute disease, there are cases of persistent infection, primarily in immunocompromised patients. It is hypothesized that at least some variants...

Editorial: Dormant Cancer Cells, Cancer Progression, and Post-Acute Sequelae of COVID-19 and Influenza Dinah V. Parums Abstract Since the COVID-19 pandemic, vaccine uptake has fallen, and awareness of the long-term consequences of respiratory virus infections, particularly long COVID, also...

Fc-γR-dependent antibody effector functions are required for vaccine-mediated protection against antigen-shifted variants of SARS-CoV-2, Macklin 2023 Samantha R. Mackin, Pritesh Desai, Bradley M. Whitener, Courtney E. Karl, Meizi Liu, Ralph S. Baric, Darin K. Edwards, Taras M. Chicz, Ryan P...

Now published. See post #35. --------------------------------------- There Is No Established Connection Between Long-COVID and Chronic Fatigue Syndrome https://www.preprints.org/manuscript/202506.2016/v1 Abstract Fatigue is the most common symptom of Long-COVID (LC), characterized by...

Multi-layered deep immune profiling, SARS-CoV-2 RNAemia and inflammation in unvaccinated COVID-19 individuals with persistent symptoms Roberta Rovito, Valeria Bono, Nicolò Coianiz, Valentina Cazzetta, Sara Franzese, Joanna Mikulak, Clara Di Vito, Francesca Bai, Guillaume Beaudoin-Bussières...

Spatial transcriptomics of the epipharynx in long COVID identifies SARS-CoV-2 signalling pathways and the therapeutic potential of epipharyngeal abrasive therapy Kensuke Nishi, Shohei Yoshimoto, Takayuki Tanaka, Shoichi Kimura, Toshiyuki Tsunoda, Akira Watanabe, Kaori Teranaka, Yo Oguma, Hanako...

Abstract In a subset of children and adolescents, SARS-CoV-2 infection induces a severe acute hyperinflammatory shock1 termed multisystem inflammatory syndrome in children (MIS-C) at four to eight weeks after infection. MIS-C is characterized by a specific T cell expansion2 and systemic...

Double-seropositive Myasthenia Gravis Following COVID-19: A case report Yuki Hiraoka, Yasushi Hosoi, Takuya Tsubata, Miharu Yanagida, Yusuke Otake, Michiko Ito [Line breaks added] Abstract Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness caused by antibodies...

Role of antiviral CD8+ T cell immunity to SARS-CoV-2 infection and vaccination Vivien Karl, Maike Hofmann, Robert Thimme [Line breaks added] Abstract The COVID-19 pandemic has greatly enhanced our understanding of CD8+ T cell immunity and their role in natural infection and vaccine-induced...

Molecular architecture of coronavirus double-membrane vesicle pore complex Yixin Huang, Tongyun Wang, Lijie Zhong, Wenxin Zhang, Yu Zhang, Xiulian Yu, Shuofeng Yuan & Tao Ni [Line breaks added] Abstract Coronaviruses remodel the intracellular host membranes during replication, forming...

Abstract COVID-19 vaccines have prevented millions of COVID-19 deaths. Yet, a small fraction of the population reports a chronic debilitating condition after COVID-19 vaccination, often referred to as post- vaccination syndrome (PVS). To explore potential pathobiological features associated with...

Sex-related differences in the association between migraine, COVID-19, and long COVID: A population-based cohort Linda Al-Hassany, Antoinette - MaassenVanDenBrink, Tobias Kurth [Line breaks added] Abstract Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, placed...

Amyloid-forming potential of Betacoronavirus including SARS-CoV-2 Hazem Haddad, Walid Al-Zyoud Abstract Prions are considered as sub-viral protein particles that have exceptional ability for multiple structural or functional conformational changes, leading to amyloid or prion forming or...

SARS-COV-2 re-infection and incidence of post-acute sequelae of COVID-19 (PASC) among essential workers in New York: a retrospective cohort study https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(24)00311-9/fulltext Background After surviving Coronavirus Disease 2019 (COVID-19)...