t cells

Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation The efficacy of B cell depletion therapies, and their association with Epstein-Barr virus (EBV), implicate B cells in the pathogenesis of multiple sclerosis (MS). In...

SARS-CoV-2 peptide fragments selectively dysregulate specific immune cell populations via Gaussian curvature targeting Immune cell populations are dysregulated in COVID-19 for currently unknown reasons: Plasmacytoid dendritic cell (pDC) populations are reduced, thus hampering antiviral...

Post-COVID impairment of memory T cell responses to community-acquired pathogens can be rectified by activating cellular metabolism Infection rates involving bacterial and viral pathogens have increased precipitously after the COVID-19 pandemic. While it has been speculated that higher...

Abstract Background: Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME), is a debilitating condition characterized by persistent fatigue and multisystemic symptoms, such as cognitive impairment, musculoskeletal pain, and post-exertional malaise. Recently, parallels have...

Immune transcriptomic changes in Australian Gulf War veterans Eaton-Fitch, Natalie; Sasso, Etianne Martini; Marshall-Gradisnik, Sonya [Line breaks added] Background Gulf War Illness (GWI) is a chronic multisystemic illness found in one-third of Gulf War Veterans. The aetiology of GWI is...

Robust antibody and T cell responses tracked longitudinally in patients with long COVID After severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, a minority of patients experience persistent or emerging symptoms, termed ‘long coronavirus disease (COVID) or post-acute...

Highlights • Plasma profiling of 7,288 proteins during post-exertional malaise in ME/CFS. • ME/CFS participants show sustained immune, metabolic, and neuromuscular dysregulation during post-exercise recovery. • Exertion disrupts T and B cell signaling, IL-17 pathways, and mitochondrial...

Baseline Dysregulation in B, T, and NK Cells in COVID-19 Predicts Increased Late Mortality but Not Long-COVID Symptoms: Results from a Single-Center Observational Study The SARS-CoV-2 pandemic presents a broad clinical spectrum from asymptomatic cases to severe respiratory failure with high...

Mechanisms of sex differences in acute and long COVID sequelae in mice While males are more likely to suffer severe outcomes during acute COVID-19, a greater proportion of females develop post-acute sequalae of COVID-19 (PASC) despite similar rates of infection. To identify mechanisms of PASC...

Mechanisms of resistance to daratumumab in patients with multiple myeloma Iversen KF Abstract Multiple myeloma (MM) is an incurable cancer in the bone marrow. The treatment of MM has developed significantly during the last 20 years, which has resulted in increased survival. Daratumumab is the...

HLA-B*15:01-positive severe COVID-19 patients lack CD8+ T cell pools with highly expanded public clonotypes Understanding host factors driving asymptomatic versus severe disease outcomes is of key importance if we are to control emerging and re-emerging viral infections. HLA-B*15:01 has been...

Do self-perpetuating B lymphocytes drive human autoimmune disease? Jonathan C W Edwards, Geraldine Cambridge, Vikki M Abrahams Published: 1999 [Line breaks added] Abstract Normal immunological memory is thought to be underpinned by T lymphocytes. However, in rheumatoid arthritis there are...

Persistent Immune Dysregulation during Post-Acute Sequelae of COVID-19 is Manifested in Antibodies Targeting Envelope and Nucleocapsid Proteins https://www.biorxiv.org/content/10.1101/2025.08.18.670908v1 Abstract Post-Acute Sequelae of SARS-CoV-2 infection (PASC) syndrome or “Long COVID”...

Lunde S, Kristoffersen EK, Sapkota D, Risa K, Dahl O, Bruland O, et al. (2016) Serum BAFF and APRIL Levels, T-Lymphocyte Subsets, and Immunoglobulins after B-Cell Depletion Using the Monoclonal Anti-CD20 Antibody Rituximab in Myalgic Encephalopathy/Chronic Fatigue Syndrome. PLoS ONE 11(8)...

DecodeME candidate ME/CFS gene CHROMOSOME 6p Chr6p contained seven Tier 1 genes. *************************** BTN2A2 (Tier 1) • Protein: Butyrophilin subfamily 2 member A2. UniProt. GeneCards. The allele that increases the risk of ME/CFS is associated with decreasing BTN2A2 gene expression...

Abstract Lactate is a critical regulator of cellular processes and immune signaling, and we hypothesize that exercise-induced elevations in lactate help activate immune cells in response to vigorous exercise. Despite its importance, the impact of lactate on T-cell mitochondrial respiration...

Single-cell RNA-sequencing highlights a curtailed NK cell function in convalescent COVID-19 pregnant women Salker, Madhuri S. ; Abd Aziz, Nor Haslinda ; Prodan, Natalia Carman ; Yang, Zhiqi ; Lankapalli, Aditya Kumar ; Lazar, Katrin ; Shafiee, Mohamad Nasir ; Kocak, Ersoy ; Ganesan, Harivignesh...

In Silico Analysis of Post-COVID-19 Condition PCC Associated SNP rs9367106 Predicts the Molecular Basis of Abnormalities in the Lungs and Brain Functions Maiti, Amit K. Long-or post-COVID-19 syndrome, which is also designated by WHO as Post COVID-19 Condition (PCC), is characterized by the...

Immunological and Clinical Markers of Post-acute Sequelae of COVID-19: Insights from Mild and Severe Cases 6 Months Post-infection William Mouton; Sophia Djebali; Marine Villard; Omran Allatif; Cécile Chauvel; Sarah Benezech; Philippe Vanhems; Jacqueline Marvel; Thierry Walzer; Sophie...

Cytokine profiles associated with persisting symptoms of post-acute sequelae of COVID-19 Ji-Soo Kwon, Euijin Chang, Hyeon Mu Jang, Ji Yeun Kim, Woori Kim, Ju Yeon Son, Junho Cha, Choi Young Jang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim...