viral persistence

Multiomic and Spatial Profiling of Colorectal Tissue Reveals Viral Persistence and Immune Dysregulation in Long COVID Abstract Long COVID (LC) - a chronic condition characterized by persistent, debilitating symptoms following SARS-CoV-2 infection - has emerged as a major public health...

Now published, see post #6. Preprint: Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19 Chronic viral infections are ubiquitous in humans, with individuals harboring multiple latent viruses that can...

Case Report: Post-Mortem Analysis of Long-Term Inflammation After Mild COVID-19 Abstract Persistent inflammation and tissue injury may contribute to post-acute COVID-19 syndrome (PACS). However, direct tissue evidence from mildly-infected individuals sampled long after recovery remains...

Longitudinal assessment of SARS-CoV-2 Spike and Nucleocapsid antigenemia in the ORCHESTRA Post-COVID cohort OBJECTIVES Spike antigenemia has been proposed as a mechanism underlying post-COVID condition (PCC). We determined whether persistent free SARS-CoV-2 Spike or Nucleocapsid antigenemia is...

Implications of RNA virus persistence for post-acute sequelae and chronic inflammatory syndromes Vidal, Daniela; Castro, Ítalo de Araújo; López, Carolina B. Abstract Viral persistence refers to the ability of a virus to remain in its host for an extended period. Although most non-retroviral...

Blinded 2-Year Longitudinal Evaluation of SARS-CoV-2 Antigenemia in Long COVID OBJECTIVES SARS-CoV-2 antigens have been detected in plasma months after acute infection, but their long-term dynamics and clinical relevance remain unclear. We aimed to assess the persistence and clinical...

Abstract The COVID-19 pandemic has infected more than 778 million people worldwide. Roughly 7% of these patients progress to Long COVID (LC), suffering from persistent symptoms and cognitive impairment well past the acute stage. As the mechanisms of LC remain elusive, we utilized single-cell...

Differences in SARS-CoV-2 antigen persistence in individuals with systemic autoimmune rheumatic diseases compared to the general population: A RECOVER-Adult Cohort Study BACKGROUND Individuals with systemic autoimmune rheumatic diseases (SARDs) are at risk for worse acute and post-acute...

Link to the article: https://mecfsscience.org/immune-findings-in-me-cfs/

Persistent SARS-CoV-2 Spike is Associated with Localized Immune Dysregulation in Long COVID Gut Biopsies [Line breaks added] Abstract SARS-CoV-2 persistence is a proposed driver of Long COVID (LC), but the in-situ relationship between residual viral antigen and immune dysregulation remains...

Persistent Gut-Immune Axis dysregulation in long-term Post-COVID Syndrome: Insights from a prospective, observational, cross-sectional case-control study Post-COVID syndrome (PCS) is a complex condition that can emerge after recovery from SARS-CoV-2 infection, even in young, healthy...

A phase 2a double-blind, placebo-controlled randomized trial of the SARS-CoV-2-specific monoclonal antibody AER002 in people with Long COVID Long COVID is a disabling chronic illness with no proven treatments. Persistence of SARS-CoV-2 has been proposed as a biological driver of the disease...

CD169+ and HLA-DR+ extracellular vesicles are highly represented in human plasma and dynamically expressed in SARS-CoV-2 infection and long COVID-associated sequelae INTRODUCTION Elevated inflammation and immune dysregulation are the main consequences of severe acute respiratory syndrome...

Abstract The Persistence of SARS-CoV-2 in tissues has been proposed as a driver of prolonged symptoms in long COVID. Pulmonary rehabilitation with exercise training is a well-established intervention for improving symptoms, functional capacity, and inflammation in chronic cardiorespiratory...

This is the preprint. Go to post #9 for the published paper Disruption of the hypothalamic orexin system links SARS-CoV-2 infection to persistent cortical neuronal pathology Long COVID frequently presents with persistent neurological symptoms, including cognitive impairment, fatigue, and...

Post-COVID impairment of memory T cell responses to community-acquired pathogens can be rectified by activating cellular metabolism Infection rates involving bacterial and viral pathogens have increased precipitously after the COVID-19 pandemic. While it has been speculated that higher...

Broadly neutralizing antibodies to SARS-CoV-2 in Long COVID are associated with viral persistence and clinical outcome Chenyu Liu, Daniel Sanson, Serhan Soylu, Leen Moens, Isabelle Meyts, Marc Jamoulle, Johan Van Weyenbergh [Line breaks added] Abstract Long COVID (also known as post-acute...

Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic condition without a definitive aetiology, no reliable diagnostic test, and no proven effective treatment. Despite most patients reporting a post-viral onset of illness, findings to date are conflicting...

A highly divergent sample from a nearly extinct SARS-CoV-2 lineage in a patient with long-term COVID-19 BACKGROUND Although COVID-19 is primarily an acute disease, there are cases of persistent infection, primarily in immunocompromised patients. It is hypothesized that at least some variants...

https://thesicktimes.org/2025/08/12/no-easy-home-runs-early-long-covid-trials-of-paxlovid-and-monoclonal-antibodies-failed-but-the-treatments-still-have-potential/