viral persistence

The Role of SARS-CoV-2 Nucleocapsid Protein Persistence in Inducing Chronic Type I Interferon and Mitochondrial Dysfunction. Andreas Koenig; Mohammad Quasem; Benjamin Zink; Doniyorbek Abdulla-Zoda; Priyanka Karunanidhi; Karolina Sienko; Christian Geier; Venkatesh Jayaraman; Rabia Malik; Kanza...

Characteristic immune cell interactions in livers of children with acute hepatitis revealed by spatial single-cell analysis identify a possible postacute sequel of COVID-19 Felix Röttele; Andreas Zollner; Carolin Mogler; Muhammed Yuksel; Cigdem Arikan; Vivien Karl; Judith Helene Aberle; Stephan...

Spatial transcriptomics of the epipharynx in long COVID identifies SARS-CoV-2 signalling pathways and the therapeutic potential of epipharyngeal abrasive therapy Kensuke Nishi, Shohei Yoshimoto, Takayuki Tanaka, Shoichi Kimura, Toshiyuki Tsunoda, Akira Watanabe, Kaori Teranaka, Yo Oguma, Hanako...

947 – Post-Acute SARS-CoV-2 Antigenemia Is Associated With Some but Not All Long COVID Symptoms Michael Peluso, Thomas Dalhuisen, Zoe Swank, Sarah Goldberg, Scott Lu, Samuel Han, Jessica Chen, Emily Fehrman, Khamal Anglin, Rebecca Hoh, Timothy J. Henrich, Dan Kelly, Steven G. Deeks, David Walt...

937 – Lack of Association of SARS-CoV-2 N- and S-Antigenemia With Long COVID Annukka Antar, Perrine Lallemand, Zoe O. Demko, Armaan Jamal, Nuria Gallego Marquez, Tamilore Adeagbo, Selin Akbas, Elizabeth Pasetes, Paul Blair, Katy Shaw-Saliba, Andrea Cox, Michael Peluso, Robin Dewar, Alan Landay...

929 – Age-Dichotomous Associations of Long COVID With Frequency of Public SARS-CoV-2 Memory TCRs Selin Akbas, Shuai Li, Hao Zhang, Tamilore Adeagbo, Ni Zhao, Alan Landay, Michael Peluso, Elizabeth Thompson, Andrea Cox, Yukari Manabe, Hongkai Ji, Annukka Antar [Line breaks added] Background...

933 – [18F]F-AraG PET Imaging Reveals Increased Gut T-Cell Activation in People With Long COVID Timothy J. Henrich, Michael Peluso, Robert Flavell, Dylan Ryder, Kofi Asare, Emily Fehrman, Thomas Dalhuisen, Rebecca Hoh, Badri Viswanathan, Youngho Seo, Jelena Levi, Jeffrey Martin, Steven G...

Clinical, histopathological, and radiological characterization of post-acute sequelae of COVID-19 Anna Czech Abstract Numerous patients exhibit enduring symptoms following a Coronavirus Disease 2019 (COVID-19) infection, termed Post-Acute Sequelae of COVID-19 (PASC). The typical manifestations...

Abstract Post-acute sequelae of COVID-19 (PASC) is a complex and multifaceted clinical challenge requiring to emphasize its underlying pathophysiological mechanisms. This study assessed hundreds of virological, serological, immunological, and tissue damage biomarkers in two patient cohorts who...

Targeting the SARS-CoV-2 reservoir in long COVID Amy D Proal, Soo Aleman, Morgane Bomsel, Petter Brodin, Marcus Buggert, Sara Cherry, Daniel S Chertow, Helen E Davies, Christopher L Dupont, Steven G Deeks, Wes Ely, Alessio Fasano, Marcelo Freire, Linda N Geng, Diane E Griffin, Timothy J...

Molecular and Immunological Signatures of Long COVID: Implications for Diagnosis and Personalized Treatment Strategies Jorine K.N. Hammink, Tim R. van Elst [Line breaks added] Summary The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to an emerging health challenge known as “long...

Human Leukocyte Antigen (HLA) at the Root of Persistent Antigens and Long COVID Apostolos P. Georgopoulos, Lisa M. James, Phillip K. Peterson (Line break added) Abstract Here we offer a perspective on recent findings of persistent SARS-CoV-2 antigens in Long COVID through the lens of...

Acute enterovirus infection followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and viral persistence John Chia, Andrew Chia, Michael Voeller, Tonny Lee, Robert Chang Aims Enteroviruses are well-known causes of acute respiratory and/or gastrointestinal infections and...

The consequences of SARS-CoV-2 within-host persistence Alex Sigal, Richard A. Neher, Richard J. Lessells Abstract SARS-CoV-2 causes an acute respiratory tract infection that resolves in most people in less than a month. Yet some people with severely weakened immune systems fail to clear the...

Towards a cure for long COVID: the strengthening case for persistently replicating SARS-CoV-2 as a driver of post-acute sequelae of COVID-19 Michelle JL Scoullar; Gabriela Khoury; Suman S Majumdar; Emma Tippett; Brendan S Crabb New insights into post-acute sequelae of coronavirus disease 2019...

Long-term serum spike protein persistence but no correlation with post-COVID syndrome Annick Fehrer; Franziska Sotzny; Friederike Hoheisel; Elisa Stein; Laura Kim; Claudia Kedor; Helma Freitag; Cornelia Heindrich; Sandra Bauer; Rebekka Rust; Martina Seifert; Patricia Grabowski; Nina Babel...

I thought it might be worthwhile to have a discussion comparing and contrasting the symptoms of an acute infection (a week or two of flu, cold, staph, etc.) and ME/CFS. Viral persistence is often mentioned in discussions of mechanism theories. I personally think there's a good chance ME/CFS is...

Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates Thibaut Naninck; Alexandra Detrille; Steve Huvelle; Marit J. van Gils; Tatiana Geara; Quentin Pascal; Jonne Snitselaar; Laetitia Bossevot; Mariangela Cavarelli; Nathalie Bosquet; Francis...

Long COVID science, research and policy Al-Aly, Ziyad; Davis, Hannah; McCorkell, Lisa; Soares, Letícia; Wulf-Hanson, Sarah; Iwasaki, Akiko; Topol, Eric J. Long COVID represents the constellation of post-acute and long-term health effects caused by SARS-CoV-2 infection; it is a complex...

Identification of SARS-CoV-2 Persistent Infectious Epithelial Syndrome (SPIES) as a Novel Disease Entity using Clinical, Histologic, and RNA Programmatic Data Thomas Wallach, Ahmed Soliman, John Agboola, Shagun Sharma, Lais Araujo Coelho, Meredith Pittman, Christos Chatzinakos, Sergios-Orestis...