viral persistence

Insights into Persistent SARS-CoV-2 Reservoirs in Chronic Long COVID Abstract Long COVID (LC), also known as post-acute sequelae of COVID-19 infection (PASC), is a heterogeneous and debilitating chronic disease that currently affects 10 to 20 million people in the U.S. and over 420 million...

Antiviral Antibody Fc Dysfunction Is Linked to Increased IgG1 Fucosylation in Long COVID BACKGROUND Persistent SARS-CoV-2 antigen is a leading hypothesis for post-acute sequelae of SARS-CoV-2 infection (PASC), commonly known as Long COVID. Impaired Fc-mediated antiviral antibody function could...

Targeting the JAK/STAT pathway in chronic viral infections: opportunities and challenges for immunomodulation Abstract The discovery of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway as a key regulator of immune function and inflammation led to the...

A thread to collect information and trial results to do with antivirals and LC, and discuss the covid-19 viral persistence hypothesis. Split from: Antivirals as an ME/CFS treatment (e.g. valacyclovir, valgancyclovir, amantadine) Null result for paxlovid in a decent sized blinded long covid...

Nirmatrelvir–ritonavir targeting viral persistence in post-COVID-19 condition long COVID in the USA RECOVER-VITAL: a randomised, double-blind, placebo-controlled, phase 2 trial Lindsey R Baden + 253 others BACKGROUND Post-acute sequelae of SARS-CoV-2 infection, more commonly known as long...

Extracellular vesicles in COVID-19 and long COVID: Structural mediators of viral persistence and immune dysfunction Abstract Extracellular vesicles (EVs) have emerged as pivotal structural mediators of immune dysregulation and viral antigen persistence in long COVID. Rather than passive...

Multiomic and Spatial Profiling of Colorectal Tissue Reveals Viral Persistence and Immune Dysregulation in Long COVID Abstract Long COVID (LC) - a chronic condition characterized by persistent, debilitating symptoms following SARS-CoV-2 infection - has emerged as a major public health...

Now published, see post #6. Preprint: Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19 Chronic viral infections are ubiquitous in humans, with individuals harboring multiple latent viruses that can...

Case Report: Post-Mortem Analysis of Long-Term Inflammation After Mild COVID-19 Abstract Persistent inflammation and tissue injury may contribute to post-acute COVID-19 syndrome (PACS). However, direct tissue evidence from mildly-infected individuals sampled long after recovery remains...

Longitudinal assessment of SARS-CoV-2 Spike and Nucleocapsid antigenemia in the ORCHESTRA Post-COVID cohort OBJECTIVES Spike antigenemia has been proposed as a mechanism underlying post-COVID condition (PCC). We determined whether persistent free SARS-CoV-2 Spike or Nucleocapsid antigenemia is...

Implications of RNA virus persistence for post-acute sequelae and chronic inflammatory syndromes Vidal, Daniela; Castro, Ítalo de Araújo; López, Carolina B. Abstract Viral persistence refers to the ability of a virus to remain in its host for an extended period. Although most non-retroviral...

Blinded 2-Year Longitudinal Evaluation of SARS-CoV-2 Antigenemia in Long COVID OBJECTIVES SARS-CoV-2 antigens have been detected in plasma months after acute infection, but their long-term dynamics and clinical relevance remain unclear. We aimed to assess the persistence and clinical...

Abstract The COVID-19 pandemic has infected more than 778 million people worldwide. Roughly 7% of these patients progress to Long COVID (LC), suffering from persistent symptoms and cognitive impairment well past the acute stage. As the mechanisms of LC remain elusive, we utilized single-cell...

Differences in SARS-CoV-2 antigen persistence in individuals with systemic autoimmune rheumatic diseases compared to the general population: A RECOVER-Adult Cohort Study BACKGROUND Individuals with systemic autoimmune rheumatic diseases (SARDs) are at risk for worse acute and post-acute...

Link to the article: https://mecfsscience.org/immune-findings-in-me-cfs/

Persistent SARS-CoV-2 Spike is Associated with Localized Immune Dysregulation in Long COVID Gut Biopsies [Line breaks added] Abstract SARS-CoV-2 persistence is a proposed driver of Long COVID (LC), but the in-situ relationship between residual viral antigen and immune dysregulation remains...

Persistent Gut-Immune Axis dysregulation in long-term Post-COVID Syndrome: Insights from a prospective, observational, cross-sectional case-control study Post-COVID syndrome (PCS) is a complex condition that can emerge after recovery from SARS-CoV-2 infection, even in young, healthy...

Now published, see post #13. Preprint: A phase 2a double-blind, placebo-controlled randomized trial of the SARS-CoV-2-specific monoclonal antibody AER002 in people with Long COVID Long COVID is a disabling chronic illness with no proven treatments. Persistence of SARS-CoV-2 has been...

CD169+ and HLA-DR+ extracellular vesicles are highly represented in human plasma and dynamically expressed in SARS-CoV-2 infection and long COVID-associated sequelae INTRODUCTION Elevated inflammation and immune dysregulation are the main consequences of severe acute respiratory syndrome...

Abstract The Persistence of SARS-CoV-2 in tissues has been proposed as a driver of prolonged symptoms in long COVID. Pulmonary rehabilitation with exercise training is a well-established intervention for improving symptoms, functional capacity, and inflammation in chronic cardiorespiratory...