Aripiprazole - Abilify

benji · Apr 7, 2025

Here is why I tried it. Fluge and Mella are now trialing daratumumab, which inhibit something cd38, which apigenin also can do at best. I have tried an awfully lot of supplements though, also more common ones that has helped others but not me, this seems to be my lucky shot.

mariovitali said: ↑

Hi all,

So here are some comments and personal views from the conference :

-Still no effort to investigate ME/CFS cases not originating from viral infections. Not good.

-Very optimistic about the case presented by Oysten Fluge and anti-CD38 therapy. I had the chance to talk to him and show some associations of his work in CD38 with other findings in ME, more specifically purinergic signaling , DHFR,nitric oxide, tetrahydrobiopterin. Interestingly , apigenin (identified by machine learning) is a CD38 inhibitor : https://www.s4me.info/threads/apige...amelioration-of-me-symptoms.7872/#post-140372 . In the end of our talk he said : "send me whatever you have" ))

Of note : One slide on Fluge's presentation has shown that there was no organ damage found in post mortem ME/CFS patients. I specifically asked him whether they looked at liver tissues and he said that they didn't. I then showed some Fibroscans of ME/CFS patients and asked him if they could test patients with Fibroscans.

-I was very happy to see the work presented by Leonard Jason (DePaul University) : machine learning and network analysis methods being used to try to identify key differentiators of ME/CFS vs HCs (see attached photo).

-Also the work by Nuno Sepuvelda who used data from Carmen Scheibenbogen and then applied machine learning algorithms. Quite possibly there will be a joint effort with Nuno who is very committed and enthusiastic for medical research and the use of mathematics / algorithms to crack ME/CFS. (see attached).

-And last but not least , I was able to speak with Dr Prusty. He is very specific to what he wants (which is good) , told me that one of the proteins he found can be found mainly in hepatocytes -as he knows my persistence with everything liver related- and told me to send him anything that I could share with him (which was nice).

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Jaybee00 · Apr 7, 2025

Interesting. I’m guessing this is different—Dara kills cells expressing cd38, whereas apigenin inhibits the synthesis of CD38

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Aripiprazole - Abilify

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