B12/Folic Acid and D3/K2 Supplementation

I'll check it out.

 

I didn't have symptoms of B12 deficiency, but when I was tested years ago I was borderline low. I took B12 shots and methB12 tablets but didn't feel any difference. So who knows.

 

The funny thing is that my GP didn't feel I needed to supplement with B12 when it was borderline low, but a couple of years later after taking B12 tablets and retested, she had the receptionist call to tell me to immediately stop taking it b/c it was 'high!".

 

I've heard/read that many doctors think that B12 is toxic.

A quote from this link : https://stichtingb12tekort.nl/engli...been-shown-to-be-safe-for-more-than-50-years/

 

A recent survey highlighted that increased dietary intake of folic acid causes adverse health effects by promoting angiogenesis, inflammation, and neurotoxicity.

What happens if you significantly increase dietary folic acid intake?

Journal reference:

• Gunnala, S. et al. (2025) How Increased Dietary Folic Acid Intake Impacts Health Outcomes Through Changes in Inflammation, Angiogenesis, and Neurotoxicity. Nutrients. 17(7), 1286. doi: https://doi.org/10.3390/nu17071286
  

 

If folate levels are low then someone improves their level it can have positive effects :

Title : Folic Acid Treatment Is Associated With Decreased Risk of Suicide Attempts

Link : https://neurosciencenews.com/folic-acid-suicide-21568/

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But taking the level too high can have adverse effects in some groups of patients :

Title : High serum folate is associated with brain atrophy in older diabetic people with vitamin B12 deficiency

Link : https://link.springer.com/article/10.1007/s12603-017-0979-z

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More evidence of adverse outcomes with excessive folic acid :

Title : Excessive folic acid intake and relation to adverse health outcome

Link : https://www.sciencedirect.com/science/article/abs/pii/S0300908416300530

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Title : The Methylene Tetrahydrofolate Reductase (MTHFR) isoform challenge. High doses of folic acid are not a suitable option compared to 5 Methyltetrahydrofolate treatment

Link : https://www.semanticscholar.org/paper/The-Methylene-Tetrahydrofolate-Reductase-(MTHFR)-of-Servy-Menezo/1a92716f3f0b38334b48a4c787ba8b966e3f97b9?p2df

The above link is useful for having quite a lot of citations and references relating to folic acid, folate and MTHFR.

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Title : Active Folate Versus Folic Acid: The Role of 5-MTHF (Methylfolate) in Human Health

Link : https://pmc.ncbi.nlm.nih.gov/articles/PMC9380836/

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