Current: Genome-wide association study in (CFS/ME) to uncover the genetic susceptibility and identify biological pathways involved

I searched but couldn't find this here, which is surprising. I've also Googled and can't find details of this elsewhere.

https://www.ukbiobank.ac.uk/2019/12...ty-and-identify-biological-pathways-involved/

 

@Andy will the announcement of whether or not UK GWAS was awarded the funding, be delayed now, because of the coronavirus?

 

So far as we know, no, but it wouldn't be surprising if it was - at the moment we are still waiting to hear one way or the other from the funders.

 

So this is another gwas study ? Is it funded ?

 

I wonder if this is the same study that was talked about at the CFS/ME Research Conference in Oslo back in Nov. 2019. Thread and post with slides here.

ETA: Also a lecture from 2018. Thread with summary in English here.

 

Prof. Benedicte A. Lie is also a co-author of the recent Nature study "Human Leukocyte Antigen alleles associated with ME/CFS" from among others Fluge and Mella.

 

Great, thanks Kalliope.

Presentation doesn't mention the UK Biobank at all though. Those numbers, as far as I understand it, while impressive currently for an ME/CFS study, aren't high enough to have high confidence in the results. Having said that, from the slides I think they are focusing more tightly on particular areas of the genome, so that might make a difference? I'm more talking out loud, rather than asking anybody in particular.

 

Small study, but great to see a genetic signal. This needs replication and more samples, but at the moment this does point towards an adaptive immune contribution to ME. Encouraging.

Mod note: Post copied to Human Leukocyte Antigen alleles study
Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Fluge, Mella et al 2020