That's interesting. I've never asked for help with sleeplessness since I was prescribed various types of sleeping pills decades ago. They knocked me out well enough, but that isn't the same as sleeping. I decided that getting used to living with it was preferable to a rubber cosh. But I'd be really interested in anything that promotes actual sleep, as opposed to not-awake-ness. I had Covid a couple of times recently, and the proper sleep it brought reminded me how much difference this makes to my level of function.
Despite Nice's statement, my GP is unable to prescribe daridorexant because the South West London Formulary has not approved it.
This is probably just a weird coincidence, but I thought the name Daridorexant sounded like a brand name for a new anti-perspirant. And having done a web search for it the shopping options at the top of the page were all for anti-perspirants. I'm curious how the trade name for the stuff - Quviviq - is supposed to be pronounced.
@Sarah94 . It was explained to me that it was well suited and why but please don't ask me to remember the explanation. It was something to do with it not working in the same way as benzos. How are you getting on with it?
And sorry, all I really meant (but didn’t communicate that clearly) was who told you. I’m guessing Dr Bansal.
I do take a lot of what Dr Bansal says with a strong helping of salt - he keeps trying to get me to try Abilify ffs!
Yes. How you feel about trying it (and aripiprazole) depends on a lot of things I suppose. Age, severity are two. I doubt there will be a treatment in my lifetime so it's a question of making judgements. I would really value even a bit of improvement, perhaps for a time. The threads on here about abilify are interesting. My sleep is appalling and deteriorating. I would try daridorexant ( I think) if I could get it prescribed but local formulary is not approving it. Privately is hugely expensive. Oddly if I moved a few miles to SELondon, it could be prescribed on NHS. You obviously have some. Is it available where you are? I am hoping that my area is just behind and will decide to approve it. I need to get an appointment to discuss with GP.
Dr Bansal wrote in his letter “I am certain this will be ideal for Sarah”. There’s a little bitch part of me that wants this to *not* work out, because I have gottten so fed up of his “certainty” over the years.
Please do. I'll probably be awake all night wondering how you are getting on with it........for 3 out of the last 4 nights , I haven't slept till after 5 or 6 am so I'll have plenty of time to think. If you're titrating up , maybe there will be a delay in getting full effect? I think he's just positive with his patients. He has been really helpful for me over time eg in getting hospital to do tests with saline, to go gently on exercise while in hospital, to know what was happening when I suddenly had an anaphylaxis. Also am very grateful for his NHS clinic in 2009 where GET wasn't offered. Good luck for tonight.
NICE Guidance prescribing information here: https://bnf.nice.org.uk/drugs/daridorexant/ It's quite expensive for the NHS: https://bnf.nice.org.uk/drugs/daridorexant/medicinal-forms/ £42 for 30 tablets. https://bnf.nice.org.uk/drugs/daridorexant/#cautions (...) Prescribing and dispensing information For daridorexant Treatment duration should be as short as possible; the need for continued treatment should be assessed within 3 months of starting daridorexant and periodically thereafter. There are 192 Interactions listed: https://bnf.nice.org.uk/interactions/daridorexant/ Patient Information Leaflet: https://www.medicines.org.uk/emc/files/pil.15359.pdf https://www.nice.org.uk/guidance/ta922 Daridorexant for treating long-term insomnia Technology appraisal guidance [TA922] Published: 18 October 2023 In PDF format: https://www.nice.org.uk/guidance/ta...treating-longterm-insomnia-pdf-82615544244421
There seems to be variation in whether this drug will be prescribed on the NHS depending on where you live. Different Formularies are currently taking different views. e,g, SE London will prescribe on NHS while SW London won't!
Quite a lot here about potential side effects (provides far more information than the Patient Information Leaflet I posted above). https://www.medicalnewstoday.com/articles/drugs-quviviq-side-effects#faq Quviviq side effects: What you should know -------------------------- NHS Dorset supports prescribing: "Daridorexant is an option for patients who are eligible for it within the NICE TA who have either tried CBTi or CBTi has failed or is unavailable." DORSET MEDICINES ADVISORY GROUP COMMISSIONING STATEMENT ON DARIDOREXANT FOR TREATING INSOMNIA DISORDER https://nhsdorset.nhs.uk/Downloads/.../Commissioning Statement for Daridorexant.pdf Also says re cost to NHS: "The list price for the 50‑mg or the 25‑mg dose is £1.40 per day (£42 per pack of 30 tablets; company submission)." Which makes it considerably more expensive than, for example, amitriptyline, mirtazapine or gabapentin prescribed for sleep disturbance.
