DMissa
Senior Member (Voting Rights)
Probably not based on what JE is saying. They were defined as doing less than an hour of exercise a week... that reflects most normally functioning adults and the time spent lying flat would likely not be matched
Evidence of White Matter Neuroinflammation in [ME/CFS]: A Diffusion-Based Neuroinflammation Imaging Study 2026 Yu et al
Thanks ScoutB.
I think this study may well have found something interesting in the RF result, but it would have been better if they had not rushed to put a label of inflammation on it. As Jonathan says, it is possible that the lower RF finding does actually say something about a version of inflammation, or something else. .
I've sent off a query to Qiang Yu, the first and corresponding author of the paper, about the relationship of the restricted fraction to inflammation, and also about the use of HADS. Hopefully Qiang will join us here.
I think this study may well have found something interesting in the RF result, but it would have been better if they had not rushed to put a label of inflammation on it. As Jonathan says, it is possible that the lower RF finding does actually say something about a version of inflammation, or something else. .
I've sent off a query to Qiang Yu, the first and corresponding author of the paper, about the relationship of the restricted fraction to inflammation, and also about the use of HADS. Hopefully Qiang will join us here.
ME/CFS Science Blog
Senior Member (Voting Rights)
Thanks Hutan and ScoutB, I was running into the same issues.
Here's how I understand it: hindered water ratio (NII-HR) indicates places were water is very free to diffuse while restricted fraction (NII-RF) are places where water is very restricted to diffuse. In inflammation both measures are increased. NII-HR because of water flowing to the inflamed area, and NII-RF because of cells moving into the tissue and in them water is restricted.
But in this ME/CFS study both NII-HR and NII-RF were reduced? So the key measured are the opposite of what is seen in neuroinflammation?
Here's how I understand it: hindered water ratio (NII-HR) indicates places were water is very free to diffuse while restricted fraction (NII-RF) are places where water is very restricted to diffuse. In inflammation both measures are increased. NII-HR because of water flowing to the inflamed area, and NII-RF because of cells moving into the tissue and in them water is restricted.
But in this ME/CFS study both NII-HR and NII-RF were reduced? So the key measured are the opposite of what is seen in neuroinflammation?
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