I agree that feeling ill tends to be due to cytokine release. But if that is the case then the guiding idea that PWME feel ill because their mitochondria cannot produce enough energy is wrong for starters. We should be looking for cytokines. But if we say maybe you can feel ill, or at least weak and fatigued, because mitochondria are unable to produce energy, which seems a very popular idea with these researchers, then you are only going to feel weak or fatigued because of poor energy production in cells that help you move around, like muscle, or provide background support for that energy production, like liver. Both muscle and liver cell failure make people feel weak and fatigued.
I completely agree that there is no good reasoning:
Why do people feel weak? ... EASY ANSWERE: ... Because there is no energy.
How can we measure any ATP? ... EASY PROCEDURE: ... We take blood cells.
How does this go together? ... IMPLICIT SUGGESTION: ... It´s simply all the same.
Popular ideas tend to be thought through badly, and there is no difference if it´s in front of a researcher´s eye or of any other person´s eye. Researcher don´t ask the right questions here, I think.
What does fatigue and weakness caused by problems with the brain's motor centers feel like? Assuming that this causes these symptoms.
That would apply in MS. ...
This may give some clue, I would say.
If we feel weak from a cold, we should know that there would be enough energy to run away. It would be though at the cost of best healing for now. It is obviously codified by the brain. And then there are other illnesses which - surprise, surprise - affect in any sense such feelings (without that there is anything wrong with ATP).
That the "something in the blood" idea is directly related to the feeling of weakness is not thought through well, and Davis must be critisized for this suggestion, even if there is something in the blood (which might be the case).
A further question then is if this something is a downstream effect from such a structure making the feeling of weakness, or if this something makes the structure to induce the feeling. Again, that this something indicates that the something also takes place in muscles (because some patients feel weak in their muscles) is unlikely in view of the illness, at least as described in the CCC or ICC. And how could it come about that there are so many possible symptoms, but e.g. many organs function completely well?
I think the paper Scheibenbogen, Prusty and Naviaux is interesting, but any suggestion that a virus here and there accounts for symptoms here and there is unlikely to be true - which they indeed also don´t say.
