Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19, 2021, Lee et al

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Pure speculation but maybe this line of research or the methods used in the paper to understand immune cell metabolic reprogramming via single-cell multiomics could eventually help explain whatever possible cellular metabolic changes that are triggered and persist in Long COVID and ME/CFS…

A better understanding of the metabolic alterations in immune cells during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may elucidate the wide diversity of clinical symptoms experienced by individuals with coronavirus disease 2019 (COVID-19). Here, we report the metabolic changes associated with the peripheral immune response of 198 individuals with COVID-19 through an integrated analysis of plasma metabolite and protein levels as well as single-cell multiomics analyses from serial blood draws collected during the first week after clinical diagnosis. We document the emergence of rare but metabolically dominant T cell subpopulations and find that increasing disease severity correlates with a bifurcation of monocytes into two metabolically distinct subsets. This integrated analysis reveals a robust interplay between plasma metabolites and cell-type-specific metabolic reprogramming networks that is associated with disease severity and could predict survival.

MedicalXpress: Metabolic changes in plasma and immune cells associated with COVID-19 severity, can predict patient survival