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Late-Onset Hypogonadism in a Male Patient with Long COVID Diagnosed by Exclusion of ME/CFS, 2022, Soejima et al

Discussion in 'Long Covid research' started by Andy, Apr 24, 2022.

  1. Andy

    Andy Committee Member

    Hampshire, UK

    After the acute phase of COVID-19, some patients have been reported to have persistent symptoms including general fatigue. We have established a COVID-19 aftercare clinic (CAC) to provide care for an increasing number of these patients.

    Here, we report the case of a 36-year-old man who developed post-COVID fatigue after acute infection with SARS-CoV-2. In the acute phase of COVID-19, the patient’s fever resolved within four days; however, general fatigue persisted for three months, and he visited our CAC 99 days after the initial infection. Examination revealed a high Aging Male’s Symptoms (AMS) score of 44 and low free testosterone (FT) level of 5.5 pg/mL, which meet the Japanese criteria of late-onset hypogonadism (LOH) syndrome. Imaging studies revealed an atrophic pituitary in addition to fatty liver and low bone mineral density. Anterior pituitary function tests showed a low follicle-stimulating hormonelevel and delayed reaction of luteinizing hormone (LH) after gonadotropin-releasing hormone (GnRH) stimulation, indicating the possibility of hypothalamic hypogonadism in addition to primary hypogonadism seen in patients with post-COVID-19 conditions. After the initiation of Japanese traditional medicine (Kampo medicine: hochuekkito followed by juzentaihoto), the patient’s symptoms as well as his AMS score and serum FT level were noticeably improved. Furthermore, follow-up tests of GnRH stimulation revealed improvements in LH responsiveness.

    Although many patients have been reported to meet the criteria of ME/CFS such as our case, we emphasize the possibility of other underlying pathologies including LOH syndrome. In conclusion, LOH syndrome should be considered a cause of general fatigue in patients with post-COVID-19 conditions and herbal treatment might be effective for long COVID symptoms due to LOH.

    Open access, https://www.mdpi.com/1648-9144/58/4/536/htm
    FMMM1, nick2155, sebaaa and 4 others like this.
  2. CRG

    CRG Senior Member (Voting Rights)

  3. Arnie Pye

    Arnie Pye Senior Member (Voting Rights)

    What are the chances that the patient already had or was developing these symptoms before Covid?

    I think there is a possibility that there will end up being two camps of researchers : 1) One group determined to exclude ME/CFS so that the sufferers can be experimented on freely and 2) Those determined to diagnose ME/CFS for political reasons.
    Trish likes this.

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