ME/CFS patients exhibit altered T cell metabolism and cytokine associations (2019) Mandarano, Hanson et al

Dr. Alexandra Mandarano did a great job presenting - clear concise - even I half-understood what was going on - I'm particularly interested in relationship between ME and CD4s and CD8s as they are key measures in pwHIV.

Interesting to see the connection between ME and allergies as co-morbidity, and family history of rheumatoid arthritis.

I took these 2 screenshots:

 

I got the impression from reading the paper that metabolism in CD4 and CD8 cells is relatively normal.

 

The screenshot posted by @ScottTriGuy seems to indicate that CD4 metabolism is relatively normal but that there are several differences for the CD8 cells. Did you take from the paper that those, too, were minor?

 

It's mostly that they tested a lot of markers for T-cell metabolism and most seemed normal. Will have to see if the abnormalities like glycolysis in CD8 cells can be confirmed by others...

 

Merged thread

Article: Immune System Altered in Chronic Fatigue Syndrome
About Maureen Hansons work.

https://www.labmedica.com/immunolog...stem-altered-in-chronic-fatigue-syndrome.html

 

anyone here w science background can interpret the paper? What significance does it have, and how much?

 

NIH Research Matters: Immune cell metabolism altered in ME/CFS

To look more closely at immune-cell metabolism in ME/CFS, researchers led by Drs. Alexandra Mandarano and Maureen Hanson at Cornell University collected blood samples from 53 people with ME/CFS and 45 people without the disease. They tested specific types of immune cells in the blood for changes in metabolism, both at rest and after being activated by signals that indicate a danger to the body.

 

I am a fan of low manganese food, and had just a look:

Decreases in CD8+T, naive (CD4+CD45RA+) T, and B (CD19+) lymphocytes by exposure to manganese fume
Nakata et al 2006, open access.

I think it could be related, only that exposure is without infection but with high amounts.