ME/CFS patients exhibit altered T cell metabolism and cytokine associations (2019) Mandarano, Hanson et al

Dr. Alexandra Mandarano did a great job presenting - clear concise - even I half-understood what was going on - I'm particularly interested in relationship between ME and CD4s and CD8s as they are key measures in pwHIV.

Interesting to see the connection between ME and allergies as co-morbidity, and family history of rheumatoid arthritis.

I took these 2 screenshots:

ME co-morbidites - family history.png ME CD4, CD8 Summary.png
 
Ravn said:
The screenshot posted by @ScottTriGuy seems to indicate that CD4 metabolism is relatively normal but that there are several differences for the CD8 cells. Did you take from the paper that those, too, were minor?
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It's mostly that they tested a lot of markers for T-cell metabolism and most seemed normal. Will have to see if the abnormalities like glycolysis in CD8 cells can be confirmed by others...
 
Merged thread

Article: Immune System Altered in Chronic Fatigue Syndrome
About Maureen Hansons work.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe, chronic, and debilitating disease that can cause a range of symptoms including pain, severe exhaustion, cognitive impairment, and post-exertional malaise, the worsening of symptoms after physical or mental activity.

Estimates suggest that between 836,000 and 2.5 million people in the USA may be affected by ME/CFS. It is unknown what causes the disease and there are no treatments. There is an increasing appreciation for the role of immune and metabolic dysfunction in the disease. ME/CFS has historically presented in outbreaks, often has a flu-like onset, and results in inflammatory symptoms.
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A group of scientists working with Cornell University (Ithaca, NY, USA) examined biochemical reactions involved in energy production, or metabolism, in two specific types of immune cells obtained from 45 healthy controls and 53 people with ME/CFS. The investigators focused on CD4 T cells, which alert other immune cells about invading pathogens, and CD8 T cells, which attack infected cells. They analyzed glycolysis and mitochondrial respiration in resting and activated T cells, along with markers related to cellular metabolism, and plasma cytokines.

The team found that ME/CFS CD8+ T cells have reduced mitochondrial membrane potential compared to healthy controls. Both CD4+ and CD8+ T cells from ME/CFS patients had reduced glycolysis at rest, while CD8+ T cells also had reduced glycolysis following activation. ME/CFS patients had significant correlations between measures of T cell metabolism and plasma cytokine abundance that differed from healthy control subjects. They also looked at mitochondrial size and membrane potential, which can indicate the health of T cell mitochondria. CD4 cells from healthy controls and people with ME/CFS showed no significant differences in mitochondrial size or function.
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https://www.labmedica.com/immunolog...stem-altered-in-chronic-fatigue-syndrome.html
 
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NIH Research Matters: Immune cell metabolism altered in ME/CFS

To look more closely at immune-cell metabolism in ME/CFS, researchers led by Drs. Alexandra Mandarano and Maureen Hanson at Cornell University collected blood samples from 53 people with ME/CFS and 45 people without the disease. They tested specific types of immune cells in the blood for changes in metabolism, both at rest and after being activated by signals that indicate a danger to the body.
 
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