Neuroinflammation in post-acute sequelae of COVID-19 (PASC) as assessed by [11C]PBR28 PET correlates with vascular disease measures, 2023, VanElzakker

Now published as —

Neuroinflammation in post-acute sequelae of COVID-19 PASC as assessed by 11C PBR28 PET correlates with vascular disease measures
VanElzakker; Bues; Brusaferri; Kim; Saadi; Ratai; Dougherty; Loggia

The COVID-19 pandemic caused by SARS-CoV-2 has triggered a consequential public health crisis of post-acute sequelae of COVID-19 (PASC), sometimes referred to as long COVID. The mechanisms of the heterogeneous persistent symptoms and signs that comprise PASC are under investigation, and several studies have pointed to the central nervous and vascular systems as being potential sites of dysfunction.

In the current study, we recruited individuals with PASC with diverse symptoms, and examined the relationship between neuroinflammation and circulating markers of vascular dysfunction. We used [11 C]PBR28 PET neuroimaging, a marker of neuroinflammation, to compare 12 PASC individuals versus 43 normative healthy controls.

We found significantly increased neuroinflammation in PASC versus controls across a wide swath of brain regions including midcingulate and anterior cingulate cortex, corpus callosum, thalamus, basal ganglia, and at the boundaries of ventricles. We also collected and analyzed peripheral blood plasma from the PASC individuals and found significant positive correlations between neuroinflammation and several circulating analytes related to vascular dysfunction.

These results suggest that an interaction between neuroinflammation and vascular health may contribute to common symptoms of PASC.

Link | Paywall (Brain, Behavior, and Immunity)

 

Neuroinflammation was identified across a wide range of brain regions and connected to measures of blood vessel dysfunction

https://polybio.org/longcovid-brain...ed-with-vascular-problems-harvard-team-finds/

 

I don't know how the results suggest the interaction between the two. For all we know, the neuroinflammation, if confirmed, could be causing ME/CFS-like symptoms while the vascular damage could be causing other PASC symptoms independently. In fact, that seems more likely to me.