News From Jarred Younger / Neuroinflammation, Pain, and Fatigue Laboratory at UAB, From Aug 2020

I thought it would be good to start a thread for news and updates from Jarred Younger and his "Neuroinflammation, Pain, and Fatigue Laboratory" at UAB since he is active on Facebook and has a newsletter

Link to Facebook page

Code:

https://www.facebook.com/Neuroinflammation-Pain-and-Fatigue-Laboratory-at-UAB-1543963919214695

https://www.facebook.com/Neuroinflammation-Pain-and-Fatigue-Laboratory-at-UAB-1543963919214695

 

A couple of weeks ago he posted on the status of the papers he talked about at the Australia conference.

The dextromethorphan paper he refers too is a low dose treatment clinical trial for FM.

Code:

https://www.facebook.com/permalink.php?story_fbid=2692627934348282&id=1543963919214695

 

Post from 3rd Aug 2020 - exciting that he has a lot of treatment trials that may be relevant for ME/CFS

Code:

https://www.facebook.com/permalink.php?story_fbid=2704341869843555&id=1543963919214695

 

Not optimistic that ANY of these will help people with MECFS.

Also not a fan of folks who call their OWN work ambitious.

 

Here is a Youtube video from 2018, with Dr. Younger explaining a bit about the study and why/how low-dose dextromethorphan might work for treating fibromyalgia.

Edit: grammar etc.

ETA:

https://www.youtube.com/watch?v=E14Ust5BN3c

 

Link ?

 

You can click the word 'Here'.

 

Thanks

 

I interpreted "ambitious" as referring to testing nine different potential treatments in a single clinical trial. Hope that clarifies.

 

I too have a real hard time seeing embedded links especially in short words. It would be great if someone could tweak the colour scheme to find a way to emphasise them better.

 

Sorry for the confusion, I embedded the video in my original post for better visibility.

 

I havn´t watched the video or read the paper, so I don´t know what "low dose" exactly means here,
but in general I find low dose applications much better than normal ones.

I once tried Dextrometorphan (in normal dose) for my ME/CFS, but it worked only for one time very well.

But I want to emphasize once more low dose and even very low dose, this might actually be a key
(although I am talking in my case about rather special supps, and upon avoidances).

Hope, they get some clue anyway.

 

Jarred Younger is still recruiting and is looking for participants close to his lab in Birmingham Alabama. He doesn't say which particular study this. At a guess I would say this is his NIH brain imaging study.
[He along with a colleague also has an immune cell study https://www.s4me.info/threads/track...ing-zr-89-oxinate-4-labeled-leukocytes.11625/]

Code:

https://www.facebook.com/permalink.php?story_fbid=2706181776326231&id=1543963919214695 

 

I actually belive this guy 100%

My Brain is definetly inflamed

Whether that’s an overactive hypothalamus or something else I’m not sure but I’m fully behind this guy

Reason being I’ve managed to switch off the brain or inflammation a few times doing various things and the symptoms of m.e did actually go, sadly it was only temporarily but I believe this man is in the right track

 

https://twitter.com/user/status/1460639133592813572


https://twitter.com/user/status/1460423407548338181


The ncnedConference refers to a conference organized by the National Centre for Neuroimmunology and Emerging Disease in Australia.

 

The study on "hot" brains wasn't altogether convincing with a very small sample size, and probably some discrepancies between the controls and patients. I'm not sure about the neuroinflammation finding/findings. The study is available here.

 

Solve M.E. webinar, June 23: How We Can See ME/CFS Inflammation in the Brain

Dr. Jarred Younger’s 2016 Ramsay Award was used to show that brain temperature is elevated in ME/CFS. This increased temperature is a sign of brain inflammation. The findings are now being replicated in a large group of individuals with ME/CFS.

Dr. Younger’s lab is now developing new magnetic resonance imaging (MRI) and positron emission tomography (PET) scans that can determine whether someone is suffering from brain inflammation. The goal of this research is to conclusively show that brain inflammation should be made a primary target for ME/CFS treatment.

In this webinar, Dr. Younger will give updates on the brain inflammation research, describe the studies coming up, and discuss directions for improved ME/CFS treatment

 

Jared has been saying since 2015 that he has various candidates to treat neuroinflammation in MECFS—haven’t seen any of these treatments yet. He’s also a yoga fan!

https://www.s4me.info/threads/yoga-...inical-trial-hayley-younger-et-al-2021.28007/

 

https://www.residency.peds.uab.edu/...unities/itemlist/tag/chronic fatigue syndrome

 

It would be worthwhile to repost in recruiting studies category so it gets seen more widely