News From Jarred Younger / Neuroinflammation, Pain, and Fatigue Laboratory at UAB, From Aug 2020

From their Facebook post, https://www.facebook.com/permalink....cH7BSFHMtSa1ieEQLpiGMvmVl&id=1543963919214695
"I am starting a new series of videos to keep everyone up-to-date on everything that is happening in the laboratory. I will be releasing one video per week. You can see the one released today at the link below. It is about decentralized clinical trials (DCT's). - Jarred Younger"

 

Here's a summary of Dr. Younger's video:

He's talking about decentralized clinical trials. A decentralized clinical trial is one you can participate in from home. You see the doctor via telehealth, receive study drugs in the mail, and do any necessary bloodwork at a local lab.

This allows those who are homebound or have difficulty arranging transportation to participate. It also eliminates the problem of sheer distance. Decentralization would allow anyone in the US to participate, instead of just those who live within driving distance of Dr. Younger's clinic.

One limitation of decentralized trials is that we can only do them for treatments with an established safety record.

Younger's lab currently has three studies planned:

• Curcumin, resveratrol and stinging nettle in Gulf War Illness, starting in "very early 2023"
  
• After that, low-dose naltrexone for ME/CFS
• Low-dose naltrexone for long Covid
• Maybe other studies in the more distant future

Unfortunately, he hasn't described the structure of the trials, like whether they're be double-blinded. My guess is, they will, because they've already done similar small trials (botanicals in GWI or LDN in fibromyalgia). I'm guessing this is how they will attempt to replicate them with larger studies.

 

Thank you so much for the summary! Incredibly helpful

 

You're welcome!

 

Saying a lil prayer for objective outcome measures, diagnosis by qualified physician, placebo-controlled trials. I am not sure how you can control for selection bias in this kind of study design.

 

Moved post

New series of short talks by professor/researcher Jarred Younger on Youtube, on neuroinflammation, pain and fatigue.

Here's the intro talk:

https://www.youtube.com/watch?v=ZWWM6duVScE

 

"2 - New Psilocybin Clinical Trial

In #2 of this Neuroinflammation, Pain, and Fatigue series, I am discussing a new clinical trial using psilocybin for chronic pain. This study will be running throughout 2024."

https://www.youtube.com/watch?v=c_TLM18P7kQ

 

https://www.youtube.com/watch?v=uyI0fqwxg-Y

 

One of the studies I am more excited to see results from!

 

An emotional experience.

I’ve found my new bed time story voice, but wow how do you talk about sickness in such a deeply relaxing tone.

I can’t remember how brutal any treatment candidate drugs would be if this theory of ME pans out but, since there may be some options I can’t help but join in with hoping that it does.

How good would it be if such a kindly fellow was able to over turn an empire of sadism? That would make perfect movie material too, see Post Office scandal thread. This leaves me feeling perhaps that’s a little too optimistic, for one in such a position as ours.

On the other hand my brain on fire is all in. The body map photo for these immune cells overlaps my worst pain areas. But I’d then have to add arm pits, neck throat, eyes and head. So perhaps another a stretch in favour of my hopes of vindication for my unrestrained bodily sensations.

Imagine how many avenues could have been explored in the past fifty years if every researcher was as open and curious and committed to the scientific process as Jarred. Well chosen ME Research UK.

 

https://www.youtube.com/watch?v=Tco6wHEOnE4

 

https://www.youtube.com/watch?v=VQxir5qb-40

 

https://www.youtube.com/watch?v=d_E4ekxzzlg

 

The 8 tests mentioned are —

High-Sensitivity C-reactive Protein (hs-CRP)
Erythrocyte Sedimentation Rate (ESR)
Serum Amyloid A (SAA)
Plasma Viscosity (PV)
Ferritin
Fibrinogen
Interleukin 6 (IL-6)
Tumor Necrosis Factor alpha (TNF-a)

 

https://www.youtube.com/watch?v=GS8rgE9HKSU

 

https://www.youtube.com/watch?v=KeGlH3oEjTM

 

https://www.youtube.com/watch?v=9fkfvFIDyWI

 

1,186 views 26 Mar 2024 BIRMINGHAM
A quick update from the lab. A large remote clinical trial grant we proposed for funding was rejected. This study was on low-dose naltrexone (LDN) and cannabidiol (CBD) for Gulf War Illness treatment. If you want to hear a bit about how I feel about rejected grants and how I handle them, check out the video. While this news is disappointing, we fortunately have more accepted grants than rejected ones, and this is just part of the highly competitive process. - Jarred Younger

 

https://www.youtube.com/watch?v=Wcgv1bW2Y_A