Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

jnmaciuch said:
Except this data doesn't support the idea that NK cells and severity correlate. The other two non-responders with low NK cell count were in the moderate group.
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I never argued NK cells and severity correlate, my point is you cannot make any conclusion about the severity and response because of the confounding variable.

That’s the whole idea of a confounder
 
jnmaciuch said:
That may be the explanation, though I'd expect dara to be considerably slower than rituximab considering the expression of CD38 was usually at least an order of magnitude lower than CD20 in my old data sets.
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My understanding is that killing is pretty quick. If it going to kill it has probably done it by the time the drip has come down. If not, it won't.
 
ryanc97 said:
I never argued NK cells and severity correlate, my point is you cannot make any conclusion about the severity and response because of the confounding variable.

That’s the whole idea of a confounder
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In order to be a confounder it would need to correlate with both the independent and dependent variable

[edit: might be worth it to drop this thread of discussion anyways, looking at the actual step count and questionnaire data I’m not sure how much the severity labels actually align with the available data anyways]
 
jnmaciuch said:
In order to be a confounder it would need to correlate with both the independent and dependent variable

[edit: might be worth it to drop this thread of discussion anyways, looking at the actual step count and questionnaire data I’m not sure how much the severity labels actually align with the available data anyways]
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Alright fine.

I’ll do a scatter of baseline SF36 vs baseline NK cell count and you should be able to see a minor correlation.
 
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@jnmaciuch

There is minor trend except for the SF36 baseline 10 patient responder with 270 NK cells that is patient 01.

But anecdotally (from a small group of 5 people I asked, there is no correlation. I am mild and have NK cells 49. There is a severe person with 250)
 
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ryanc97 said:
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@jnmaciuch

There is minor trend except for the SF36 baseline 10 patient responder with 270 NK cells that is patient 01.

But anecdotally (from a small group of 5 people I asked, there is no correlation. I am mild and have NK cells 49. There is a severe person with 250)
Click to expand...
Thanks for the plot. So it seems like we can conclude that NK cells at baseline is not a significant confounder for the apparent difference between responder groups in baseline questionnaire scores.

Why the questionnaire scores don’t seem to correlate with step counts at baseline is another source of confusion though. I have a feeling that small sample size is heavily weighing on this data
 
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