Relationship between major depressive disorder and [ME/CFS]: a two-sample mendelian randomization study analysis, 2025, Zhu et al

I did find that the lead author, Wenjing Song, has done at least two mendelian randomization studies before.

For Daytime napping and the incidence of Parkinson’s disease: a prospective cohort study with Mendelian randomization, I looked at the SNPs in the paper, and compared them to the SNPs in the 23andMe paper they cite on daytime napping, and most of them match.

For the other, I didn't see any SNPs listed.

 

Ok thanks, that's useful to know.

 

Seriously impressive digging again on here.

I’m afraid I can’t help, to pass on a couple of things Chris has mentioned to me in general. First, because UK buying bank data is so accessible, it’s used in a lot of GWAS Studies, and some of these are of questionable quality. Second, Mendelian randomisation studies are sophisticated and hard to get right.

These are general comments and don’t tell us anything about this study, but the apparent errors are not a great sign. Hopefully, the authors will clarify things