SequenceME genetic study - from Oxford Nanopore Technologies, the University of Edinburgh and Action for ME

[Utsikt]

If the genetic analyses showed differences between ME/CFS triggered by COVID and ME/CFS not triggered by COVID, wouldn't that raise the question of further subtyping or different diseases based on triggers?

If they are wastly different - probably yes.

If there are some minor differences, they might just be due to the covid-ME/CFS being confounded by signals related to the susceptibility to covid infections.

If we had enough samples, the WGS from EBV-ME/CFS might also look different than the WGS for ME/CFS in general.

So minor differences would be interesting, but might not mean there are subtypes of ME/CFS itself.

 

[Jonathan Edwards]

If the genetic analyses showed differences between ME/CFS triggered by COVID and ME/CFS not triggered by COVID, wouldn't that raise the question of further subtyping or different diseases based on triggers?

Long Covid genetics might throw up genes that reflect Covid viral protein recognition leading to a different level of immune response but the same ME/CFS in the end. For instance there might be an HLA allele or haplotype link.