The biology of coronavirus COVID-19 - including research and treatments

Can't find it now. Will check later again.

 

Dr. Kaufman on testing of coronavirus, first 3 minutes are credits.

https://www.youtube.com/watch?v=Xr8Dy5mnYx8

 

Thank you @Snow Leopard for your comments re the above antiviral.

Do you have any comments on the TB vaccine study, with link below?

Thank you very much for your replies.

 

Thank you for checking on this, @lansbergen.

You may find this site helpful. Apologies, it does have some commercialism, but not extensively so.:
https://www.hemopet.org/covid-19-updates-testing-companion-pets-pet-fur-march-23-2020/

 

Some posts moved from the Worldwide spread and control thread

Could this be a virus that becomes dormant in someone, rather than eradicated, and then reactivates again?

 

@Barry COVID19 is an enveloped RNA virus.

These small, enveloped RNA viruses replicate via reverse transcription of their RNA genomes; the resulting DNA establishes persistence by integrating into the host genome, from which it generally cannot be dislodged. In most infected cells in culture, such integrants continue to express genomic RNA and viral proteins, leading to the production of progeny virions. However, in some cultured cells such integrants are completely transcriptionally silent, though they can be exogenously stimulated to express viral mRNAs and resume virus production. These cells meet the molecular definition of latency.

 

Er ... thank you @Mij ... although I understand about 90% of the words, the missing 10% and the way the 90% go together ... means I don't have a clue what you are trying to explain to me . Thank you, but it's way over my head .

 

@Barry umm, I will leave to Dr. Edwards to explain

 

They seem to be aiming for non-specific immune stimulation, it looks like they're scraping the barrel. The problem is that even if has an effect, it will only make a small difference.

There was no cross reactivity of antibodies to childhood vaccines (including BCG) towards SARS-1.0 (note: in mice)
https://jcp.bmj.com/content/60/2/208.full

 

Still can not find it but found another one

In dutch

https://www.rijksoverheid.nl/onderw...d-19/veelgestelde-vragen-per-onderwerp/dieren

And another one

https://www.hartvannederland.nl/nieuws/2020/katten-mogelijk-toch-gevoelig-voor-coronavirus/

 

Thank you very much @Snow Leopard for your reply.

Cheers.

 

University of Alberta study of coronavirus treatment for cats may hold some answers:

https://www.folio.ca/antiviral-used...ould-hold-key-to-covid-19-u-of-a-researchers/

 

https://eenvandaag.avrotros.nl/item...nden-voor-verband-overgewicht-en-coronavirus/

Overweight seems to be a riskfactor.

Smoking is not.

 

The risk factor on that case is likely hypertension/cardiovascular disease, rather than merely weight, and it's just speculation until someone publishes detailed data.

 

There's this from ProMED mail today, and beneath is a list of other mails concerning dogs and cats. From what I recall about the 2 dogs concerned the first one was probably just picking up the virus environmentally. The second one got ill though, but I can't find the mail about that one right now. It's probably somewhere in that list of mails.

Here's the one about the cat.

 

"UBC-led study finds trial drug can significantly block early stages of COVID-19 in engineered human tissues"

https://www.med.ubc.ca/news/ubc-led...ages-of-covid-19-in-engineered-human-tissues/

@Snow Leopard @Mij

 

How are they administering this? It needs to be in the respiratory membranes, not in the blood. The therapy would rely on steric effects, namely coating the spike proteins on the virus with the soluble ACE2, so that the virus cannot use these receptors to bind to the cell.

It might work, I have no idea whether it would cause significant side effects though.

 

Apparently cats can be infected and infect other cats.

 

@Snow Leopard

Thank you for your comments.