USA: Mount Sinai PACS clinic and Dr David Putrino

Putrino isn't an immunologist or even, as far as I know, a medic. Why is he writing this stuff?
There are no useful data. What is the justification?

 

He is a cutting-edge Long Covid researcher!!

 

In what sense?
Cutting edge researchers do not normally produce social media threads of garbled messages about off label treatments.

 

I’m guessing @Jaybee00 ’s comment was sarcastic

 

Yes, that was sarcastic.

 

https://twitter.com/user/status/1921444670741086470

 

It would be nice with an explanation for why lactic acid causes PEM..

 

It doesn't according to Mark Vanness:

https://www.youtube.com/watch?v=q_cnva7zyKM

 

I don’t think it makes any sense for lactic acid to be involved in causing PEM directly because it doesn’t explain the delay the often occurs.

And why don’t people experience PEM after intense exercise when they are healthy?

 

I hope the Putrino slide is taken out of context and it’s a hypothesis, not stating a “fact”. Though to be honest Putrino is not known for properly hedging claims, he’s more known for making BioBS type claims…

 

For what it's worth, in the PEM conference the other day, I believe three different groups (Putrino, Puta and another one) showed either preliminary or clinical data from their clinics - all of them seeing increased plasma lactate during rest and activity compared to healthy adults. It was explained with dysfunctional TCA / increased anaerobic glycolysis iirc (pyruvate -> lactate -> exported lactate). I don't remember them trying to explain that this increased lactate is anything else but an outcome of the former - I don't think they made lactate more than a potential diagnostic marker. Not a main driver of disease state I think. Not 100% certain I remember correctly.