USA: Mount Sinai PACS clinic and Dr David Putrino

I hope the Putrino slide is taken out of context and it’s a hypothesis, not stating a “fact”. Though to be honest Putrino is not known for properly hedging claims, he’s more known for making BioBS type claims…
 
I'm not sure where the lactic acid is supposed to be. I don't think there is good evidence for increased levels of lactic acid in the blood of people with ME/CFS, or for abnormal responses to exercise in terms of lactic acid?

I know there was that n=1 paper by Vink, but I think members' experimentation with lactic acid monitors, including my own, didn't find that issues with lactic acid were a common problem.
 
Hutan said:
I'm not sure where the lactic acid is supposed to be. I don't think there is good evidence for increased levels of lactic acid in the blood of people with ME/CFS, or for abnormal responses to exercise in terms of lactic acid?

I know there was that n=1 paper by Vink, but I think members' experimentation with lactic acid monitors, including my own, didn't find that issues with lactic acid were a common problem.
Click to expand...

For what it's worth, in the PEM conference the other day, I believe three different groups (Putrino, Puta and another one) showed either preliminary or clinical data from their clinics - all of them seeing increased plasma lactate during rest and activity compared to healthy adults. It was explained with dysfunctional TCA / increased anaerobic glycolysis iirc (pyruvate -> lactate -> exported lactate). I don't remember them trying to explain that this increased lactate is anything else but an outcome of the former - I don't think they made lactate more than a potential diagnostic marker. Not a main driver of disease state I think. Not 100% certain I remember correctly.
 
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My lactate was 1 decimal point below the top end of normal when first seen in the emergency dept. Really, that was quite abnormal for a supposedly fit and healthy 50yo (at the time). I was doing nothing and the normal range encompasses the full adult age and fitness range.

@Kiwipom I wonder if you might have a comment on your experience with looking at lactate.
 
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