Variation in Repeated Handgrip Strength Testing Indicates Submaximal Force Production in Patients With [ME/CFS], 2025, Popkirov

[forestglip]

I don't think it is. It seems to be a reanalysis of data from a Charite study:

B. Jäkel, C. Kedor, P. Grabowski, et al., “Hand Grip Strength and Fatigability: Correlation With Clinical Parameters and Diagnostic Suitability in ME/CFS,” Journal of Translational Medicine 19, no. 1 (2021): 159, https://doi.org/10.1186/s12967-021-02774-w.

Oh yes sorry, just saw your post. Yes, that was incorrect to say it was the NIH study.

 

[ME/CFS Science Blog]

Had a closer look at the raw data, available here:

Hand grip strength and fatigability: correlation with clinical parameters and diagnostic suitability in ME/CFS - Journal of Translational Medicine

Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex and debilitating disease accompanied by muscular fatigue and pain. A functional measure to assess muscle fatigability of ME/CFS patients is, however, not established in clinical routine. The aim of this study is...

translational-medicine.biomedcentral.com

EDIT: posted some other graphs earlier but these were incorrect (they focused on the variation per group rather than per individual).

Below is a graph of the standard deviations for each participant across the 10 repetitions of the first round. The variance looks bigger in ME/CFS but it's not a dramatic difference.



The Coefficient of Variation (CV) divides these SDs by the mean and because ME/CFS patients had consistently smaller mean strength than controls, the CV comparison shows a major difference.

 

[Evergreen]

The difference seems quite large. So apart from the authors interpretation what would be the most likely explanation for this? Is it simply that being ill/having lots of symptoms causes the variation in handgrip strength measurements?

Indeed. The difference disappears for males but not females when they account for peripheral fatigue. This excludes nearly half of the females and males with ME/CFS from the second analysis on the following basis:

the sum of the first two measurements divided by the sum of the last two measurements within one session is used as an index of fatigability (IF)

only patients with an IF within 2 SD of the mean [index of fatigability] in healthy controls of the respective gender will be included in a second analysis.

If the half that were included in the second analysis had significantly different indices of fatigability from the healthy controls, would that explain it?

 

[Evergreen]

EDIT: posted some graphs and data but with some errors. Will update later

Oh good, I couldn't understand it so I'll come back later after a rest!

 

[ME/CFS Science Blog]

The Coefficient of Variation (CV) divides these SDs by the mean and because ME/CFS patients had consistently smaller mean strength than controls, the CV comparison shows a major difference.

Was looking at one of the reference in the paper, a review Shechtman 2000 which was highly critical rather than supportive of the measure. It also points out what seems to be the issue here:

The problem with using the CV when the average and standard deviation do not change proportionally is that CV values become inflated. The formula for the CV has the standard deviation as the nominator and the average as the denominator. Therefore, for the CV to be greater, either the standard deviation has to be greater or the average has to be smaller. Average grip strength is reduced both during submaximal effort and with hand injury. Consequently, the CV may increase because of the decreased average, not because of a true increase in variability (standard deviation). The fictitious data presented in Table 5 show that when the CV is used to assess sincerity of effort in weaker people, the CV values may be inflated because of the decrease in average strength. [...] In fact, Mitterhauser et aL17 found that the CV of three grip repetitions was significantly greater in injured than in uninjured subjects. [...] Shechtman52 showed that, following carpal tunnel release surgery, the CV increased as grip strength decreased, while the standard deviation remained the same

So I think that's whats happening here: the standard deviations between patients and controls are comparable. If you divide, however, by the mean to get the CV, then it becomes inflated in ME/CFS patients because they have much less force. Larger mean grip forces do not necessarily show greater absolute variability, so the CV measure seems inappropriate to compare populations with different strength.

It also seems that reviews around the year 2000 concluded that this was not a reliable measure and that it hasn't been used much since.

 

[ME/CFS Science Blog]

Below is a graph of the standard deviations for each participant across the 10 repetitions of the first round. The variance looks bigger in ME/CFS but it's not a dramatic difference.

In the graph above the greater variance in ME/CFS could be due to the decline in strength over the 10 repetitions. If I take only the first 3 repetitions, the variation between groups looks similar.

 

[Evergreen]

So I think that's whats happening here: the standard deviations between patients and controls are comparable. If you divide, however, by the mean to get the CV, then it becomes inflated in ME/CFS patients because they have much less force. Larger mean grip forces do not necessarily show greater absolute variability, so the CV measure seems inappropriate to compare populations with different strength.

Excellent debunking. Will you write a letter to the journal?

Letters to the Editor: max. 500 words, including a maximum of five references. Letters express views about articles published in EJoN or present ideas or findings of scientific interest that do not constitute original research. Letters to the Editor are published online only.