Webinar - ME/CFS Involves Brain Inflammation: Results from a Ramsay Pilot Study - Jarred Younger

I have read a bit about fractalkine.

Fractalkine seems to play a neuroprotective and an inflammatory role.

Here, https://www.nature.com/articles/nn0706-859 the authors show:
The authors use three different in vivo models of CNS insult to show that without the receptor for a chemokine called fractalkine, excessive microglial activation occurs in response to both inflammatory and neurotoxic stimuli.
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For this, the authors ablated the fractalkine receptor (which sits on microglial cells). Other papers show or discuss the neuroprotective role in Alzheimer's disease and Parkinson's. E.g., decreased levels of fractalkine seem to indicate a higher severity or progression of the disease.
(E.g. https://www.ncbi.nlm.nih.gov/pubmed/26084002; in the retina: https://www.ncbi.nlm.nih.gov/pubmed/28216676)

In people with ME, a small study found decreased levels of fractalkine.
In addition, we identified significant reductions in the concentrations of fractalkine (CX3CL1)...
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https://www.ncbi.nlm.nih.gov/pubmed/26615570

So it could be that activated microglial cells and decreased fractalkine are not contradictory.
 
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