Webinar - ME/CFS Involves Brain Inflammation: Results from a Ramsay Pilot Study - Jarred Younger

Yes. Its not explained. A mistake? A major clue? Secondary to brain inflammation? We need to know.

 

I have read a bit about fractalkine.

Fractalkine seems to play a neuroprotective and an inflammatory role.

Here, https://www.nature.com/articles/nn0706-859 the authors show:

For this, the authors ablated the fractalkine receptor (which sits on microglial cells). Other papers show or discuss the neuroprotective role in Alzheimer's disease and Parkinson's. E.g., decreased levels of fractalkine seem to indicate a higher severity or progression of the disease.
(E.g. https://www.ncbi.nlm.nih.gov/pubmed/26084002; in the retina: https://www.ncbi.nlm.nih.gov/pubmed/28216676)

In people with ME, a small study found decreased levels of fractalkine.

https://www.ncbi.nlm.nih.gov/pubmed/26615570

So it could be that activated microglial cells and decreased fractalkine are not contradictory.

 

Webinar is now available on YouTube

Code:

https://youtu.be/rxdzaWD5wfU

https://www.youtube.com/watch?v=rxdzaWD5wfU