long covid

Phenotypic Evolution, Clinical Subtypes, and Independent Predictors of Long COVID: A Retrospective Cohort Study Abstract Background: Post-acute sequelae of COVID-19 (PASC), commonly known as long COVID, affects an estimated 10–30% of SARS-CoV-2 non-hospitalised and 50–70% of hospitalised...

β-Cell Dysfunction in COVID-19 and Post-COVID Syndrome: Molecular Mechanisms Linking Inflammation, Oxidative Stress, and Insulin Secretion Tsvetkova, Victoria; Todorova, Katya Highlights What are the main findings? Persistent inflammation, oxidative stress, mitochondrial dysfunction, and...

Early HHV-6 IgG and IgA responses during acute SARS-CoV-2 infection in relation to long COVID: a multicohort observational study Summary Background Long COVID is a heterogeneous condition associated with both early immune responses to SARS-CoV-2 and antibody responses to herpesviruses...

SARS-CoV-2 disrupts the integrity of a human blood-brain barrier model in the absence of infection Abstract Neurological symptoms are recognized in patients with COVID-19, and include anosmia, ageusia, cognitive impairments as well as more severe complications including encephalitis and...

Beyond genes: EpiSwitch® and Orion platform-powered 3D genome architecture biomarkers reveal shared biology across ME/CFS, long COVID, PTSD, rheumatoid arthritis, and multiple sclerosis Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Long COVID (LC19)...

Extracellular vesicles in COVID-19 and long COVID: Structural mediators of viral persistence and immune dysfunction Abstract Extracellular vesicles (EVs) have emerged as pivotal structural mediators of immune dysregulation and viral antigen persistence in long COVID. Rather than passive...

Searching for biomarkers of long COVID: findings from a nationwide population-based study Abstract Long COVID, characterized by persistent symptoms following SARS-CoV-2 infection, affects an estimated 400 million people worldwide. The absence of reliable biomarkers has hindered progress...

Medical invalidation is associated with structural barriers in postacute immune mediated syndromes based on patient perspectives in Germany Abstract Post-acute immune-mediated syndromes (PAIMS), including Long COVID/Post-COVID (LC/PC), Myalgic Encephalomyelitis/Chronic Fatigue Syndrome...

Cognitive-behavioral therapy for patients with post-COVID-19 condition (CBT-PCC): a feasibility trial Abstract Background The post-COVID-19 condition describes the persistence or onset of somatic symptoms (e.g. fatigue) after acute COVID-19. Based on an existing cognitive-behavioral...

Cardiovascular Sequelae After SARS-CoV-2 in Children: From Myocardial Injury to Dysautonomia and Implications for Phenotype-Guided Follow-Up Mól, Nina; Kwinta, Przemko Abstract To summarise current paediatric evidence on long-term cardiovascular sequelae after SARS-CoV-2 infection, with...

Circulating Drivers of Pathophysiology in Post-COVID-19 Sequelae Abstract Introduction: According to the WHO, post-COVID-19 sequelae impose an increased burden of illness and comorbidities among survivors. The present study evaluated systemic clinical complications associated with the...

Risk factors for post-COVID-19 condition: A case-control study in municipalities of Paraíba and Rio de Janeiro, Brazil Abstract Introduction Post-COVID-19 condition, refers to one or multiple symptoms that continue for several weeks or months following the COVID-19 infection. This study...

Comparative analysis of SNPs associated with COVID-19 and chronic liver disease identifies DPP9 as a candidate genetic marker for Long COVID Introduction Long COVID is a multisystemic condition characterized by persistent symptoms after acute SARS-CoV-2 infection, whose biological mechanisms...

Host–virus resilience networks and viral inflammaging circuits in aging and long COVID: a CMV-centered perspective Müller, Ludmila; Di Benedetto, Svetlana; Müller, Viktor Abstract Aging and long COVID are increasingly recognized as states of disrupted host homeostasis characterized by chronic...

Acupressure and Qigong in post-infectious fatigue with impaired physical function: a randomized clinical trial Background Post-COVID Syndrome (PCS) is characterized by a variety of symptoms including fatigue and impaired physical function. The aim of the ACUQiG-study was to investigate the...

Long COVID, chronic fatigue syndrome, and chronic lyme disease as Post-acute Infection Syndromes (PAIS): a translational synthesis Sewell, Patrick E.; Reddy, Rohan Background Post-acute infection syndromes (PAIS) comprise a heterogeneous group of chronic, multisystem conditions characterized...

Clinical-cognitive profiles in long COVID and their associations with inflammatory-endothelial biomarkers and vascular measures Abstract Long COVID is clinically heterogeneous, and reproducible biomarker patterns remain limited. This cross-sectional study aimed to identify clinical-cognitive...

Hope of success and fear of failure in post-COVID patients ABSTRACT Background: Post-COVID syndrome (PCS) affects mental health, but knowledge of PCS remains limited. Investigating key motives, such as personal achievement, might help in understanding the behavior of patients with PCS. This...

A cardiometabolic perspective on post-exertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long COVID Westermeier, Francisco; Pretorius, Etheresia; Untersmayr, Eva; Bertinat, Romina; Sepúlveda, Nuno; Fisman, Enrique Abstract Post-exertional malaise (PEM), the...

Cardiovascular, Renal, and Pulmonary Risks of Long COVID: A Retrospective Cohort Study Stratified by Age and Sex Abstract Background A substantial proportion of patients with acute COVID‐19 develop postacute sequelae of SARS‐CoV‐2 infection (Long COVID). The risk of adverse cardiovascular and...