long covid

Haunting innate immune memories of COVID-19 In addition to acute hyperinflammatory responses, SARS-CoV-2 infections can have long-term effects on our immune system leading to, for example, post-acute sequelae of COVID-19 (PASC). In this issue of Cell, Cheong et al. show that severe infections...

Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization Abstract Post-COVID cognitive deficits, including ‘brain fog’, are clinically complex, with both objective and subjective components. They are common and debilitating, and can affect the...

SARS-CoV-2 RNA Persists in the Central Nervous System of Non-Human Primates Despite Clinical Recovery Abstract Adverse neurological and psychiatric outcomes, collectively termed the post-acute sequelae of SARS-CoV-2 infection (PASC), persist in adults clinically recovered from COVID-19...

Characteristics and Treatment of Exercise Intolerance in Patients With Long COVID Edward, Justin A.;Peruri, Adithya;Rudofker, Eric;Shamapant, Nikhil;Parker, Hugh;Cotter, Ryan;Sabin, Katherine;Lawley, Justin;Cornwell, William K. III The post-acute sequalae of SARS-CoV-2, also known as “Long...

Nirmatrelvir/ritonavir and risk of long COVID symptoms: A retrospective cohort study We conducted a retrospective cohort study to assess whether treatment with nirmatrelvir/ritonavir was associated with a reduced risk of long COVID. We enrolled 500 adults with confirmed SARS-CoV-2 who were...

eClinicalMedicine Long-term symptom severity and clinical biomarkers in post-COVID-19/chronic fatigue syndrome:results from a prospective observational cohort Legler et al Summary Background Post-COVID-19 syndrome (PCS) is characterised by a wide range of symptoms, primarily fatigue and...

A novel flow cytometric method for detecting fibrin(ogen) amyloid microclots using long COVID as a model HIGHLIGTS Imaging flow cytometry utilizing a novel rapid flow cytometric detection method is a promising method for detecting amyloid fibrin(ogen) microclots in conditions associated with...

Muscle Abnormalities Contribute to Post-Exertional Malaise in Long COVID A poster presentation of the very soon to be published work by Rob Wüsts team has been uploaded to Twitter. Paper now published, see post #8

Abstract Background Although COVID-19 is primarily an acute respiratory infection, 5%–40% of patients develop late and prolonged symptoms with frequent neurological complaints, known as long COVID syndrome. The presentation of the disease suggests that COVID infection may cause functional...

Long COVID treated successfully with antivirals in a rituximab-treated follicular lymphoma patient with persistent negative-antibodies to SARS-CoV2 Highlights Persistence of SARS-CoV-2 infection among immunocompromised patients are due to inability of the immune system to eliminate the virus...

Retrospective study of COVID-19 experiences in elite multinational aquatic athletes Juhász, Vencel; Csulak, Emese; Szabó, Liliána; Ocsovszky, Zsófia; Balla, Dorottya; Nagy, György; Zorzi, Alessandro; Hoepelman, Andy I. M.; Merkely, Béla; Vágó, Hajnalka; Sydó, Nóra This study assessed the...

Decreased physical performance despite objective and subjective maximal exhaustion in post-COVID-19 individuals with fatigue Vollrath, Shirin; Matits, Lynn; Schellenberg, Jana; Kirsten, Johannes; Steinacker, Jürgen M.; Bizjak, Daniel A. Introduction Fatigue is a common symptom in post-COVID-19...

Prevalence and Risk Factors of de Novo Widespread Post-COVID Pain in Non-Hospitalized COVID-19 Survivors: A Nation-Wide Exploratory Population-Based Survey Brian D. Ebbesen; Rocco Giordano; Juan Antonio Valera-Calero; Jakob Nebeling Hedegaard; César Fernández-de-las-Peñas; Lars Arendt-Nielsen...

https://www.sciencedirect.com/science/article/abs/pii/S1550830723001799 THE NOVEL APPLICATION OF THE LIGHTNING PROCESS TO TREAT LONG COVID IN PRIMARY CARE - CASE REPORT Available online 23 August 2023. F. Finch, P. Parker, C. Nollett, S Burns https://doi.org/10.1016/j.explore.2023.08.009...

High proportions of post-exertional malaise and orthostatic intolerance in people living with post-COVID-19 condition: the PRIME post-COVID study Demi ME Pagen; Maarten Van Herck; Celine JA van Bilsen; Stephanie Brinkhues; Kevin Konings; Casper DJ den Heijer; Martijn A Spruit; Christian JPA...

Reduced athletic performance post-COVID-19 is associated with reduced anaerobic threshold Robert M Barker-Davies; Peter Ladlow; Rebecca Chamley; Edward Nicol; David A Holdsworth Detailed characterisation of cardiopulmonary limitations in patients post-COVID-19 is currently limited, particularly...

Incidence of long COVID and associated psychosocial characteristics in a large U.S. city Tsai, Jack; Grace, Abigail; Espinoza, Rita; Kurian, Anita Purpose Persistent residual effects from Coronavirus Disease-2019 (COVID-19) have been observed with varying definitions of “Long COVID” and little...

Long-term health consequences among individuals with SARS-CoV-2 infection compared to individuals without infection: results of the population-based cohort study CoMoLo Follow-up Heidemann, Christin; Sarganas, Giselle; Du, Yong; Gaertner, Beate; Poethko-Müller, Christina; Cohrdes, Caroline...

The study expands on a previously-awarded proposal to thoroughly explore the underlying pathophysiology of post exertional malaise (PEM), the hallmark symptom of ME/CFS. LEAD INVESTIGATORS Laurel Crosby, PhD Ronald W. Davis, PhD...

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to postacute sequelae in multiple organ systems, but evidence is mostly limited to the first year postinfection. We built a cohort of 138,818 individuals with SARS-CoV-2 infection and 5,985,227 noninfected...