multiple sclerosis

EEG-based frontal excitation/inhibition balance as an objective biomarker for cognitive fatigue across multiple sclerosis and Long COVID BACKGROUND Cognitive fatigue is a prevalent and disabling symptom in neurological and post-viral conditions, including multiple sclerosis (MS) and Long...

Abstract Multiple sclerosis (MS) occurs when the central nervous system (CNS) is damaged by misguided adaptive immune responses, likely caused by a combination of environmental factors in genetically susceptible individuals. A known prerequisite for disease is Epstein-Barr virus (EBV)...

Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation The efficacy of B cell depletion therapies, and their association with Epstein-Barr virus (EBV), implicate B cells in the pathogenesis of multiple sclerosis (MS). In...

Neurological sequela of COVID-19 in adults with multiple sclerosis BACKGROUND Possible interactions in neuropsychiatric presentations of multiple sclerosis (MS) and COVID-19 may occur, which has been proposed in previous, albeit limited, literature. OBJECTIVES Examine COVID-19 disease...

full article: https://www.news-medical.net/news/20251230/Periodontal-bacterial-load-associated-with-disease-severity-in-multiple-sclerosis.aspx

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis Abstract Importance Vitamin D deficiency is a risk factor for multiple sclerosis (MS) and is associated with the risk of disease activity, but data on the benefits of supplementation are conflicting. Objective...

Vitamin D intake and multiple sclerosis risk in the Norwegian Mother, Father and Child cohort BACKGROUND Higher vitamin D has consistently been associated with a lower multiple sclerosis (MS) risk, but some controversy remains about whether this is due to vitamin D itself or sunlight. METHODS...

https://www.news-medical.net/news/20251022/People-with-multiple-sclerosis-found-to-have-dysbiotic-oral-microbiome.aspx

Normal appearing white matter and disability in multiple sclerosis BACKGROUND AND OBJECTIVES Multiple sclerosis (MS) is characterized by lesions and atrophy on conventional MRI, yet these often fail to explain disability. Diffusion MRI (dMRI) detects microstructural injury with diffusion...

https://www.news-medical.net/news/20251107/New-method-promises-to-alleviate-the-symptoms-of-multiple-sclerosis.aspx

Characterizing post-COVID-19 syndrome in multiple sclerosis: Vaccine status, infection burden, and therapy categories as predictors Deepak Sharma ∙ Christian P. Kamm ∙ Robert Hoepner ∙ Iris-Katharina Penner ∙ Thomas Nyffeler ∙ Lara Diem [Line breaks added] Background Post-COVID-19 syndrome...

https://www.msn.com/en-gb/health/medical/biology-teacher-becomes-first-uk-patient-to-receive-gamechanger-therapy-for-ms/ar-AA1P4nc7?ocid=msedgntp&pc=U531&cvid=68fb7249618f479794914ca2e693c6df&ei=10 https://www.independent.co.uk/news/health/multiple-sclerosis-gamechanger-therapy-nhs-b2850928.html

Genetic Risk Variants for Multiple Sclerosis and Other Loci Linked to Intrathecal Immunoglobulin G Synthesis BACKGROUND AND OBJECTIVES Intrathecal synthesis of immunoglobulin G (IgG) is a key feature of multiple sclerosis (MS) and a prognostic marker for the disease course. Although previous...

Cognitive fatigue is among the most pervasive and disabling symptoms experienced by individuals with multiple sclerosis (MS), yet it remains underrecognized and undertreated in both research and clinical settings. Despite its prevalence, cognitive fatigue is often confused with general fatigue...

https://www.msn.com/en-gb/health/other/doctors-believe-they-are-on-the-brink-of-a-new-class-of-treatments-for-ms/ar-AA1NlKJc?ocid=BingNewsSerp

GWAS highlights the neuronal contribution to multiple sclerosis susceptibility https://pmc.ncbi.nlm.nih.gov/articles/PMC11643295/ Multiple Sclerosis (MS) is a chronic inflammatory and neurodegenerative disease affecting the brain and spinal cord. Genetic studies have identified many risk loci...

Key Points Question What are the patterns of health care use in the 25 years preceding the clinically determined onset of multiple sclerosis (MS)? Findings In this cohort study of 2038 patients with MS and a matched cohort of 10 182 individuals without MS, all-cause physician visits were...

https://www.news-medical.net/news/20250729/Genetic-profiling-offers-hope-for-understanding-multiple-sclerosis-risk.aspx

Effectiveness of non-pharmacological Interventions For Fatigue in Long term conditions (EIFFEL) - systematic review and network meta-analysis Joanna Leaviss, Christopher Burton, EIFFEL study group, University of Sheffield [Line breaks added] Objective To assess the clinical effectiveness of...

The phenotypic and genetic association between endometriosis and immunological diseases Nina Shigesi, Holly R Harris, Hai Fang, Anne Ndungu, Matthew R Lincoln, The International Endometriosis Genome Consortium, The 23andMe Research Team, Chris Cotsapas, Julian Knight, Stacey A Missmer, Andrew P...