multiple sclerosis

Postprandial somnolence in people with multiple sclerosis Tatiana Christmas, Neena Singh, Saul Reyes, Kimberley Allen-Philbey, Gavin Giovannoni Objectives To identify whether people with MS (pwMS) suffer from postprandial somnolence (PPS) more than people without MS (controls), to examine...

Effects of COVID-19 Infection on Symptom Severity and Disability in Multiple Sclerosis Amber Salter, Samantha Lancia, Gary R. Cutter, Robert J. Fox, Ruth Ann Marrie Background and Objectives Infections, including infection with SARS-CoV-2 (COVID-19), could alter the course of multiple...

The impact of COVID-19 infection on multiple sclerosis disease course across 12 countries: a propensity-score-matched cohort study David Levitz, Anneke Van Der Walt et 39 al BACKGROUND The relationship between coronavirus disease 2019 (COVID-19) infection and multiple sclerosis (MS) relapse and...

Abstract Background and Objectives There is a strong link between Epstein-Barr virus (EBV) and multiple sclerosis (MS), but the underlying mechanisms are unclear. Patients with MS typically have a polyspecific intrathecal production of immunoglobulin G (IgG), part of which is directed against...

https://link.springer.com/article/10.1007/s11011-024-01428-2 12-week melatonin intake attenuates cardiac autonomic dysfunction and oxidative stress in multiple sclerosis patients: a randomized controlled trial Research Published: 04 December 2024 Abstract Multiple sclerosis (MS) can induce...

Manuscript has been accepted pendingpublications Covid-19 may raise risk of developing multiple sclerosis

Full title: Comparative effectiveness of cognitive behavioural therapy, modafinil, and their combination for treating fatigue in multiple sclerosis (COMBO-MS): a randomised, statistician-blinded, parallel-arm trial Background Fatigue is one of the most disabling symptoms reported by people...

Abstract Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. Inflammation is gradually compartmentalized and restricted to specific tissue niches such as the lesion rim. However, the precise cell type composition of such niches, their interactions and changes...

In summary, we report that MS patients are hallmarked by an accumulation of immune responses specifically directed against EBV EBNA381–452 and cross-reacting with CNS GlialCAM370–389–, CRYAB2–21–, MBP205–224–, and ANO2135–154–derived epitopes. Although, our findings provide additional insights...

Dynamics of choroid plexus volume is associated with the presence and development of fatigue in multiple sclerosis Martina Rubin; Paolo Preziosa; Monica Margoni; Alessandro Meani; Elisabetta Pagani; Gianluca Corazzolla; Loredana Storelli; Damiano Mistri; Massimo Filippi; Maria A Rocca...

Epstein–Barr virus as a potentiator of autoimmune diseases William H. Robinson, Shady Younis, …Tobias V. Lanz Show authors Nature Reviews Rheumatology (2024)Cite this article Metricsdetails Abstract The Epstein–Barr virus (EBV) is epidemiologically associated with development of autoimmune...

Chronic fatigue syndrome and multiple sclerosis have reduced craniospinal compliance and dilated pressurized bridging cortical veins https://www.sciencedirect.com/science/article/pii/S0306987723002396?via=ihub Abstract Chronic fatigue syndrome (CFS) and multiple sclerosis (MS) share...

"On June 19, 2024, the Multiple Sclerosis Community Advisory Board (MS CAB) met with the EBV-MS project research team for a pivotal consultation. The objective of this meeting was to ensure meaningful engagement and involvement of expert patients in the ongoing EBV-MS clinical trials...

In the multicenter observational study, conducted across 13 hospitals in Spain and Italy, Dr. Enric Monreal and his team found that elevated serum neurofilament light chain (sNfL) levels—a protein indicating nerve cell damage—at the onset of MS can predict both relapse-associated worsening (RAW)...

Highlights • The impact of cognitive impairment in MS increases with greater disease progression (i.e., mobility disability). • Cognitive rehabilitation effectively improves one specific domain of learning and memory (i.e., list-learning). • Combining cognitive rehabilitation and aerobic...

Frontal-striatal glucose metabolism and fatigue in patients with multiple sclerosis, long COVID, and COVID-19 recovered controls Rudroff, Thorsten This study compared brain glucose metabolism using FDG-PET in the caudate nucleus, putamen, globus pallidus, thalamus, and dorsolateral prefrontal...

Now published - see here ***** An HERV-W ENV transcription in atypical memory B cells linked to COVID-19 evolution and risk for long COVID can express the encoded protein from a ribosome readthrough of mRNA from chromosome X. Joanna Brunel; Julien Paganini; Melissa Galloux; Benjamin Charvet...

Psychosomatic nonsense strikes again:

Abstract Background Epstein-Barr virus (EBV) is a likely prerequisite for multiple sclerosis (MS) but the underlying mechanisms are unknown. We investigated antibody and T cell responses to EBV in persons with MS (pwMS), healthy EBV-seropositive controls (HC) and post-infectious mononucleosis...

Comments on energy conservation treatments for MS-related fatigue and a new proposal https://www.sciencedirect.com/science/article/abs/pii/S0022510X24001758 Highlights We propose that fatigue in MS involves a sensory component reflecting the state of the immune system. The predetermined...