multiple sclerosis

The role of Sphingolipids in myelination and myelin stability and their involvement in childhood and adult demyelinating disorders Paola Giussani; Alessandro Prinetti; Cristina Tringali Multiple sclerosis (MS) represents the most common demyelinating disease affecting the central nervous system...

The lung microbiome regulates brain autoimmunity Hosang, Leon; Canals, Roger Cugota; van der Flier, Felicia Joy; Hollensteiner, Jacqueline; Daniel, Rolf; Flügel, Alexander; Odoardi, Francesca Lung infections and smoking are risk factors for multiple sclerosis, a T-cell-mediated autoimmune...

Interesting twitter thread highlighting mechanism . Seems to be relevant to POTS too. Given overlaps the mechanism is interesting - calcium channels , which have been discussed in ME/CFS research. For some cold exposure reverses effect ( thinking of "cold" treatment collaborative research by...

I wasn't sure what prefix to use given that the paper has been accepted in Cell but not published. I read about it in a paywalled news article as the abstract was presented at the ECTRIMS 2023. Ineffective Immune Control of Epstein-Barr Virus-Induced Autoreactive Responses is an Important Cause...

N-acetylglucosamine inhibits inflammation and neurodegeneration markers in multiple sclerosis: a mechanistic trial Abstract Background In the demyelinating disease multiple sclerosis (MS), chronic-active brain inflammation, remyelination failure and neurodegeneration remain major issues...

Abstract Background A growing evidence base supports the use of autologous haematopoietic stem cell transplantation (aHSCT) for treatment of relapsing-remitting multiple sclerosis (RRMS), but it has not yet been integrated into most national clinical guidelines. The objective of this study was...

Full title: Cognitive rehabilitation and aerobic exercise for cognitive impairment in people with progressive MS(CogEx): a randomised blinded sham-controlled trial Summary Background Cognitive dysfunction in people with relapsing-remitting multiple sclerosis can improve with cognitive...

Abstract Two coronaviruses were isolated from brain material obtained at autopsy from two multiple sclerosis patients. The viruses were neutralized by serum and spinal fluid from these patients. Although most of the population have antibody to these virus isolates, multiple sclerosis patients...

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics Petersen, Mark A.; Ryu, Jae Kyu; Akassoglou, Katerina The blood coagulation protein fibrinogen is deposited in the brain in a wide range of neurological diseases and traumatic injuries with blood–brain barrier (BBB)...

Long-term effectiveness of a cognitive behavioural therapy (CBT) in the management of fatigue in patients with relapsing remitting multiple sclerosis (RRMS): a multicentre, randomised, open-label, controlled trial versus standard care Abstract Background Fatigue is a disabling symptom of...

Full title: Effects of inpatient energy management education and high-intensity interval training on health-related quality of life in persons with multiple sclerosis: A randomized controlled superiority trial with six-month follow-up Highlights Inpatient energy management education (IEME) +...

Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions Fransen, Nina L; Hsiao, Cheng-Chih; van der Poel, Marlijn; Engelenburg, Hendrik J; Verdaasdonk, Kim; Vincenten, Maria C J; Remmerswaal, Ester B M; Kuhlmann, Tanja; Mason, Matthew R J; Hamann...

Full Title: Physical activity is related to disease severity and fatigue, but not to relapse rate in persons with relapsing remitting multiple sclerosis- a self-reported questionnaire based study, 2023, Marit L. Schlagheck et al Introduction: Based on theoretical models, physical activity has...

Seen the following article recently shortly after a sibling participated in a similar study https://mecfsskeptic.com/psychosomatic-history-of-multiple-sclerosis/ this too though much older - https://forum.mssociety.org.uk/t/mi...research-at-the-heart-of-disability-cuts/9260 shocking and a...

Hello everybody, I have severe ME/CFS since 2016 and recently a multiple sclerosis (July 2022). I would like to point out that the previous MRIs were perfectly normal (between 2016 and 2022). Does anyone have both diseases? I tag Jonathan Edwards (WE discussed by email in 2018) Thanks, David

Mood Symptoms and Chronic Fatigue Syndrome due to Relapsing-Remitting Multiple Sclerosis Are Associated with Immune Activation and Aberrations in the Erythron Abstract: Background: Multiple sclerosis (MS) is a chronic autoimmune and neuroinflammatory disease of the central nervous system...

Developing, optimising and implementing a blended digital self-management tReatmEnt for FatigUe in multiplE scLerosis (REFUEL-MS) https://fundingawards.nihr.ac.uk/award/NIHR203290 https://www.refuel-ms.com/ Chief Investigator(s): Professor Rona Moss-Morris Co-investigators Start Date...

Association Between Time Spent Outdoors and Risk of Multiple Sclerosis Prince Sebastian; Nicolas Cherbuin; Lisa F. Barcellos; Shelly Roalstad; Charles Casper; Janace Hart; Gregory S. Aaen; Lauren Krupp; Leslie Benson; Mark Gorman; Meghan Candee; Tanuja Chitnis; Manu Goyal; Benjamin Greenberg...

Extensive Brain Pathologic Alterations Detected with 7.0-T MR Spectroscopic Imaging Associated with Disability in Multiple Sclerosis Eva Heckova; Assunta Dal-Bianco; Bernhard Strasser; Gilbert J. Hangel; Alexandra Lipka; Stanislav Motyka; Lukas Hingerl; Paulus S. Rommer; Thomas Berger; Petra...

Post copied from the DecodeME thread: I agree the 85% response rate is fantastic - unheard of really. Decode ME is such a brilliant study. On a related note, I found the following UCSF and University of Cambridge study on MS, published yesterday, interesting: Scientists identify first genetic...