neuroinflammation

Abstract This is a significant finding not only on the Alzheimer's front. Previously, the exact role of the immune system in early-onset Alzheimer's was unclear. Early-onset Alzheimer's is one of the diseases also showing overlaps with CFS/ME. This is one of the reasons why a differential...

Interesting review of research on the impact of inflammation on the dopamine system as well as a theoretical model and computational method trying to connect it all. Could be a hypothesis as to why Abilify and dopaminergic agents have some partial efficacy in ME, even if it is temporary (so...

Moved from this thread: Baricitinib reverses HIV-associated neurocognitive disorders in a SCID mouse model and reservoir seeding in vitro, 2019, Govegnano et al. Neuroinflammation is an interesting topic when it comes to neurocognitive disorders for sure. "Neuroinflammation...

This contains quite a lot of discussion of ME/CFS, including in the abstract.

An interesting read given the past TSPO-PET neuroinflammation studies on ME using first generation [11C]PK-11195 and now more recently second generation [11C]DPA-713, the pros/cons and limitations of these radioligands, and the development of novel third generation ligands. Recent Developments...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871676/ Abstract:

This article is a preprint and has not been certified by peer review [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice. https://www.medrxiv.org/content/10.1101/2020.10.27.20220715v1

Open access, https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-020-01998-9

Full title: Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells Paywall, https://www.jni-journal.com/article/S0165-5728(20)30689-5/fulltext Sci hub, https://sci-hub.se/10.1016/j.jneuroim.2020.577428

Full title: Innate immune signaling and sex differences contribute to neurocognitive impairment, neuroinflammation, and mitochondrial rewiring in a mouse model of Gulf War illness https://www.biorxiv.org/content/10.1101/2020.08.28.271833v1

I seem to have weeks going into months of brain inflammation which is horrendous. My brain feels inflamed which at night particularly seems to go throughout my body, some of the day as well. The feeling is deeply uncomfortable and quite excruciatingly painful with some throbbing, spreads across...

Couldn’t find the abstract.

I thought it would be good to start a thread for news and updates from Jarred Younger and his "Neuroinflammation, Pain, and Fatigue Laboratory" at UAB since he is active on Facebook and has a newsletter Link to Facebook page...

Link to article here ... more at the link

Dana M. Cairns [1,2], Nicolas Rouleau [1,2], Rachael N. Parker [1], Katherine G. Walsh [3], Lee Gehrke [4] and David L. Kaplan [1,2]* 1. Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA. 2. Allen Discovery Center, Tufts University, Medford, MA 02155, USA. 3...

NeuroToxicology Available online 25 April 2020

Full title: Coexistence of cerebral hypometabolism and neuroinflammation in the thalamo-limbic-brainstem region in young women with functional somatic syndrome Note: Due to vague selection criteria this may, or may not, be an investigation into ME. Open access...

Open access, https://www.jci.org/articles/view/129401

https://www.sciencedirect.com/science/article/pii/S0889159119313340 article about the study Brain inflammation in veterans with Gulf War illness Date: February 13, 2020 Source: Massachusetts General Hospital https://www.sciencedaily.com/releases/2020/02/200213175919.htm

https://www.preprints.org/manuscript/202002.0175/v1