pem

From 2015 but I only read it recently: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295644/

http://journals.sagepub.com/doi/abs/10.1177/1359105318805819?journalCode=hpqa

Dr Alan Moreau presented preliminary results of his work on micro-RNAs (miRNA) at the recent Stanford (2:26) and CMRC conferences. Micro-RNAs are small molecules that regulate gene expression by binding to messenger RNA and blocking their translation into proteins. miRNAs might be new to you and...

now seems like a good time to post this. had it for a while but seid etc. are popping up. has the following idea been ruled out? === pem, pene (meicc) and exertion intolerance (iom) seem to refer to exertion causing crashes. sometimes it is claimed that if you do not have it, then you do not...

I was playing around with a medical dictionary to try and come up with an alternative for 'fatigue' which is more or less the common denominator in all ME/CFS diagnostic criteria. Note: I was not trying to invent a new name for the illness! Anyway, having come up with a couple I thought I'd...

Once I get truly exhausted, my throat starts to hurt (whether or not I've been talking a lot). It starts to feel dry and my speaking grows hoarse. If I continue speaking (in a meeting, what-have-you) I start to feel like I'm going to throw up. Eventually it becomes overwhelming and I have to...

Provisionally accepted. Cardiopulmonary Exercise Test Methodology for Assessing Exertion Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Staci Stevens1, Chris Snell1, Jared Stevens1, Betsy keller2 and J. Mark VanNess3* 1Workwell Foundation, United States 2Department of...

Part 2 of the blog about Dr Ian Lipkin's Collaborative, now up at ME/CFS Research Review The heart of ME/CFS? Lipkin’s Collaborative probes the impact of exertion The hallmark symptom of ME/CFS is post-exertional malaise (PEM), a prolonged, grim and disproportionate response to exertion. While...

My question really is about the semantics of 'crash' and 'PEM'. I guess I used to use both these words somewhat interchangeably and wanted to ask PRers what they think. In my experience with ME, PEM, or a worsening of symptoms, happens after mental or physical overexertion and only when I have...

PEM: It's Time to Retire the Term by Pete Hanauer It is long past time to retire the term PEM and replace it with somethingthat accurately reflects what happens to ME/CFS patients after physical or mental exertion and that respects their dignity. We suggest the term Post Exertional Disability...

Posts on PEM moved from this thread as they had gone off topic.

I was surprised that there doesn't seem to be a thread on this paper given it discusses a few times the survey that was run here. In this case, I found it difficult to know whether to put this in the biomedical or psychosocial research section. I didn't think it was a good fit for either...

I’ve been preparing to move now for 4 months. And I’ve been doing renos for 10 days. I don’t do any physical work, or very little, but I go to the house everyday to make sure workers are okay and know what to do. I also run errands so I don’t pay these guys to go shopping. I brought my...

Meta-analysis investigating post-exertional malaise between patients and controls First Published July 5, 2018 http://journals.sagepub.com/doi/full/10.1177/1359105318784161

Dr. David M. Systrom of Brigham and Women’s Hospital (Boston) is confident that his team has objective evidence of small-fiber polyneuropathy (SFPN) in 40-50% of ME patients. Dr Systrom was interviewed by Llewelyn King in this video: . I put the timestamp at the part involved with SFPN but the...

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197811

Mark VanNess, PhD presented at the annual meeting of the American College of Sports Medicine. Lariel Mateo presented at the University of the Pacific’s Undergraduate Research and Creativity Conference. http://www.workwellfoundation.org/research-and-latest-news/

For those interested in participating in ME/CFS research. https://redcap.is.depaul.edu/surveys/?s=YJNCDPHXTH

May 2017 Neural consequences of post-exertion malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Dane B.CookabAlan R.LightcKathleen C.LightcGordonBroderickdMorgan R.ShieldsbRyan J.DoughertybJacob D.MeyerbStephanieVanRiperbAaron J.StegnerbLaura D.EllingsoneSuzanne D.Vernonf...

I’m currently crashing and I’m just curious about how you would describe your crashes/flares/PEM/bust phases? What does it feel like? (Bearing in mind I won’t be able to read long answers ;)) To me it feels like the top of my spine is inflamed and also the area which is likely my spleen. Light...